{"_buckets": {"deposit": "25cfcb3b-54f5-4e77-b7d1-96d603509b01"}, "_deposit": {"id": "4406", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4406"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00004406", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Effects of Methylene Blue on the Relaxation and Increses in CyclicGMP Concentrations of Vascular Smooth Muscle Produced by NO-formingVasodilators and Atriopeptin"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-03-31", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "32", "bibliographicPageStart": "1", "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "1992-03-31"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In the isolated endothelium-removed rabbit aorta (RA) precontracted with phenylephrine, 15 min treatment with methylene blue (15min-MB) resulted in a rightward shift of the dose-response curve (DRC) for nitroglycerin (NTG) and nitric oxide (NO), while DRC for NaN0_2, sodium nitroprusside (SNP) and atriopeptin(ANP) was not affected. DRC for SNP was not affected in the dog coronary artery (DCA) (endothelium-removed and precontracted with KG1), while DRC for SNP was shifted to the right in the rat and guinea pig aorta. The relaxation by SNP or NaNO_2 was attenuated after 60 min-MB in RA but not in DCA. The relaxation by ANP was not affected after 60 min-MB. While increases in tissue cyclic GMP in RA by NTG and NO were attenuated after 15 min-MB, the increases by SNP, NaNO_2 and ANP were not affected even after 60 min-MB. The relaxant effects of 8-Br cyclic GMP were not attenuated after 60min-MB. Thus, the inhibition by MB of relaxation by SNP and NaNO_2 was due to its action on a process or processes operative before and/or in parallel with the accumulation of cyclic GMP. Species differences in the penetrability of MB were suggested.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "学位の種類: 博士（医学）. 報告番号: 甲第855号. 学位記番号: 新大院博（医）甲第651号. 学位授与年月日: 平成4年3月31日", "subitem_description_type": "Other"}, {"subitem_description": "新潟医学会雑誌. 1992, 106(7), 631-641.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博（医）甲第651号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101A855"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "48391", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sasage, Hiroki"}]}]}, "item_6_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟大学"}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "捧, 博輝"}], "nameIdentifiers": [{"nameIdentifier": "48390", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "000000251430.pdf", "filesize": [{"value": "2.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2800000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/4406/files/000000251430.pdf"}, "version_id": "c7bbabf7-d675-4b13-9b7f-bd41a58a030d"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "vascular smooth muscle", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NO-forming vasodilators", "subitem_subject_scheme": "Other"}, {"subitem_subject": "atriopeptin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "methylene blue", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cyclic GMP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "血管平滑筋", "subitem_subject_scheme": "Other"}, {"subitem_subject": "心房性ナトリウム利尿ホルモン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "メチレンブルー", "subitem_subject_scheme": "Other"}, {"subitem_subject": "サイクリックGMP", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "NO-forming vasodilators と atriopeptin による血管平滑筋の弛緩とcyclic GMP 増加に対する methylene blue の効果について", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "NO-forming vasodilators と atriopeptin による血管平滑筋の弛緩とcyclic GMP 増加に対する methylene blue の効果について"}, {"subitem_title": "NO-forming vasodilators と atriopeptin による血管平滑筋の弛緩とcyclic GMP 増加に対する methylene blue の効果について", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/23777", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-10-10"}, "publish_date": "2013-10-10", "publish_status": "0", "recid": "4406", "relation": {}, "relation_version_is_last": true, "title": ["NO-forming vasodilators と atriopeptin による血管平滑筋の弛緩とcyclic GMP 増加に対する methylene blue の効果について"], "weko_shared_id": 2}