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A total of 40 male Wister rats were maintained with one of 4 different diets: Group 1 with high fat and high fiber diet, Group II high fat and fiberless diet, Group III with high fiber and fatless diet and Group IV with diet without fat and fiber. After feeding different diets for 5 weeks, these groups were further subdivided in accordance with the type of carcinogens. 1, 2-dimethyhydrazine (20 mg/kg/week) or EDTA, administered over 10 consecutive weeks. Anaerobic bacteria were evaluated at 4, 11 and 24 weeks after initiation of feeding the diets. All rats were killed and autopsied at 30 feeding weeks. The value of anaerobic bacteria was high in rats fed high fat diets and low in those fed high fiber diets. Compared with control group, anaerobic bacteria indicated a rather low value in cancer-bearing rats except for Group III. High fat diets were accompanied by a high risk for total tumor induction and diets without fat by a low risk, but Group IV without fat and fibers indicated an almost identical cancer volume with Group 1 fed high fat and high fiber diet. 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