{"_buckets": {"deposit": "6c6f9092-ef0c-4919-b1b2-ae3b24b35233"}, "_deposit": {"id": "4099", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4099"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00004099", "sets": ["454", "484"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "768", "bibliographicPageStart": "763", "bibliographicVolumeNumber": "94", "bibliographic_titles": [{"bibliographic_title": "日本内科学会雑誌"}, {"bibliographic_title": "日本内科学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "肺胞蛋白症（Pulmonary alveolar proteinosis, PAP)は肺胞および呼吸細気管支内にサーファクタント(Surfactant, SF)が貯留する希な肺疾患である。臨床的には先天性，二次性，特発性に分類される．二次性は血液疾患や感染症に続発し，特発性は抗GM-CSF自己抗体により発症する．　GM-CSF欠損マウスの研究により，GM-CSFシグナル異常，肺胞マクロファージの成熟障害，サーファクタントの代謝障害が主要な病態であることがわかった．また，特発性で出現する自己抗体は，GM-CSFを強力に中和しPAPを発症する．これらの研究より，肺におけるGM-CSFの重要な役割が明らかになった．治療として全肺洗浄が有効であるが，近年はGM-CSF療法が良好な成績をあげている．本稿では，肺内におけるGM-CSFの役割とPAPの病態，最近の治療法について概説する．", "subitem_description_type": "Abstract"}]}, "item_5_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本内科学会"}]}, "item_5_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00195836", "subitem_source_identifier_type": "NCID"}]}, "item_5_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00215384", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "渡辺, 雅人"}], "nameIdentifiers": [{"nameIdentifier": "47463", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中田, 光"}], "nameIdentifiers": [{"nameIdentifier": "47464", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ZI_94(4)_763-768.pdf", "filesize": [{"value": "2.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2100000.0, "url": {"label": "ZI_94(4)_763-768.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/4099/files/ZI_94(4)_763-768.pdf"}, "version_id": "5763d7da-2630-4f4d-abd2-683bc070bc9a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "肺胞蛋白症", "subitem_subject_scheme": "Other"}, {"subitem_subject": "GM-CSF", "subitem_subject_scheme": "Other"}, {"subitem_subject": "抗GM-CSF自己抗体", "subitem_subject_scheme": "Other"}, {"subitem_subject": "GM-CSF呼入療法", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "肺胞蛋白症の病態と治療（医学と治療の最前線）", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "肺胞蛋白症の病態と治療（医学と治療の最前線）"}, {"subitem_title": "肺胞蛋白症の病態と治療（医学と治療の最前線）", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "1", "path": ["454", "484"], "permalink_uri": "http://hdl.handle.net/10191/17975", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-05-16"}, "publish_date": "2012-05-16", "publish_status": "0", "recid": "4099", "relation": {}, "relation_version_is_last": true, "title": ["肺胞蛋白症の病態と治療（医学と治療の最前線）"], "weko_shared_id": null}