{"created":"2021-03-01T06:40:42.121659+00:00","id":34227,"links":{},"metadata":{"_buckets":{"deposit":"accb31cf-4bc3-4723-abb0-7185866aefc7"},"_deposit":{"id":"34227","owners":[],"pid":{"revision_id":0,"type":"depid","value":"34227"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00034227","sets":["453:456","471:537:538:2028"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Simultaneous Analyses of Plasma Concentrations of 48 Growth Factors and Cytokines in very Low Birth Weight Infants"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"27","bibliographicPageStart":"19","bibliographicVolumeNumber":"134","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】極低出生体重児について，未熟児網膜症の発症の有無と網膜光凝固の要否で3群に分けて，血漿中の成長因子，サイトカイン濃度を測定した．【方法】長岡赤十字病院新生児集中治療室に入室した18例を対象とした．児の健康状態が良好な場合に限り採血を行った．12症例から検体を得，48項目のmultiplex assayを行った．修正在胎週数33週から35週での検体について群ごとに濃度を比較した．【結果】児の健康状態維持を最優先とするため採血を実施できた症例数および採血回数は少数に限られた．そのため統計解析は実施せず，各群間での傾向を把握することとした．採血時期が修正在胎週数33から35週の間の9症例で見ると肝成長因子(Hepatocyte growth factor; HGF)，interleukin-1 alpha; IL-1α，stromal cell-derived factor 1-alpha; SDF-1α，stem cell growth factor-beta; SCGF-βの4項目で光凝固群では値が小さい傾向があった．【結論】血管成長因子とされるIL-1αが未熟児網膜症に関しては抑制的に働く可能性，網膜保護作用を有する肝成長因子や網膜の発生に不可欠なSDF-1が不足することで未熟児網膜症が悪化する可能性が考えられるが，症例数の増加と経時的な検討を加える必要がある．","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"178069","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yoshino, Hideaki"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉野, 秀昭"}],"nameIdentifiers":[{"nameIdentifier":"71241","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"134(1)_19-27.pdf","filesize":[{"value":"5.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"134(1)_19-27","url":"https://niigata-u.repo.nii.ac.jp/record/34227/files/134(1)_19-27.pdf"},"version_id":"4df1b102-feca-4fc4-a1a8-ea9cbc4703b8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"極低出生体重児","subitem_subject_scheme":"Other"},{"subitem_subject":"未熟児網膜症","subitem_subject_scheme":"Other"},{"subitem_subject":"血管内皮成長因子","subitem_subject_scheme":"Other"},{"subitem_subject":"肝成長因子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"極低出生体重児の血漿成長因子・サイトカイン濃度の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"極低出生体重児の血漿成長因子・サイトカイン濃度の検討"}]},"item_type_id":"7","owner":"1","path":["456","2028"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-12-18"},"publish_date":"2020-12-18","publish_status":"0","recid":"34227","relation_version_is_last":true,"title":["極低出生体重児の血漿成長因子・サイトカイン濃度の検討"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T04:04:35.583364+00:00"}