{"_buckets": {"deposit": "d5d1c0cb-1285-4738-90d0-8ed91a0eff68"}, "_deposit": {"id": "34164", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "34164"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00034164", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "SGLT2阻害剤、トホグリフロジンの安静時心拍数に対する影響及び脂肪組織インスリン抵抗性との関連"}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2020-09-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Aims To examine the effects of a sodium–glucose co-transporter 2 (SGLT2) inhibitor, tofogliflozin, on resting heart rate by exploring baseline factors that independently influenced changes in the resting heart rate. Methods Data on 419 participants in tofogliflozin phase 2/3 trials were analysed. Changes in resting heart rate from baseline to week 24 were analysed using an analysis of covariance (ANCOVA) model with groups (tofogliflozin/placebo) as a fixed effect and baseline values as covariates. The antilipolytic effect was evaluated as adipose tissue insulin resistance (Adipo-IR) and was calculated as the product of fasting insulin and free fatty acid. Multivariate analysis evaluated independent factors for changes in resting heart rate from baseline to week 24. Results Of the participants, 58% were men, and mean age, HbA_\u003c1c\u003e, BMI and resting heart rate were 57.6 years, 65 mmol/mol (8.1%), 25.5 kg/m^2 and 66 bpm, respectively. At week 24, adjusted mean difference vs. placebo in the change from baseline was 2.3 bpm [95% confidence interval (CI) 4.6, 0.1] with tofogliflozin. Changes in resting heart rate were positively correlated with changes in Adipo-IR, whereas reductions in HbA_\u003c1c\u003e, body weight and blood pressure were similar independent of changes in resting heart among quartiles of resting heart rate change. On multivariate analysis, higher baseline resting heart rates and Adipo-IR values were significantly associated with greater reductions in resting heart rate. Conclusions Tofogliflozin corrected resting heart rate levels in accordance with baseline levels. Correction of high resting heart rates may be attributed to improved adipose tissue insulin resistance, leading to correction of hyperinsulinaemia.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Diabetic Medicine. 2020, 37(8), 1316–1325.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(医)甲第971号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4801号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "178230", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "野島, 俊秋"}]}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1111/dme.14279", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "【○!C】 2020 The Authors. Diabetic Medicine published by John Wiley \u0026 Sons Ltd on behalf of Diabetes UK"}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nojima, Toshiaki"}], "nameIdentifiers": [{"nameIdentifier": "178229", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-11-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r2nmk971.pdf", "filesize": [{"value": "486.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 486500.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/34164/files/r2nmk971.pdf"}, "version_id": "319d5cf5-3bbc-454f-bc7f-47edfe8e0f5d"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-11-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r2nmk971_a.pdf", "filesize": [{"value": "458.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 458200.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/34164/files/r2nmk971_a.pdf"}, "version_id": "b4ebf867-e3bc-4908-af77-0e86c9f9c5d7"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Influence of an SGLT2 inhibitor, tofogliflozin, on the resting heart rate in relation to adipose tissue insulin resistance", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Influence of an SGLT2 inhibitor, tofogliflozin, on the resting heart rate in relation to adipose tissue insulin resistance"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/00051962", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-11-12"}, "publish_date": "2020-11-12", "publish_status": "0", "recid": "34164", "relation": {}, "relation_version_is_last": true, "title": ["Influence of an SGLT2 inhibitor, tofogliflozin, on the resting heart rate in relation to adipose tissue insulin resistance"], "weko_shared_id": null}