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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood

http://hdl.handle.net/10191/00051953
342bb7e5-a728-4622-846b-e392f725eb70
名前 / ファイル ライセンス アクション
r2nmk962.pdf 本文 (4.9 MB)
r2nmk962_a.pdf 要旨 (456.2 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-11-12
タイトル
タイトル Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood
言語
言語 eng
キーワード
主題Scheme Other
主題 childhood nutrition
キーワード
主題Scheme Other
主題 gut microbiota
キーワード
主題Scheme Other
主題 kidney disease
キーワード
主題Scheme Other
主題 metabolic syndrome
キーワード
主題Scheme Other
主題 obesity
キーワード
主題Scheme Other
主題 rice protein
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 幼少期における米胚乳タンパク質の摂取が成熟期の高脂肪食負荷による肥満および肥満関連腎症に及ぼす影響
著者 Higuchi, Yuki

× Higuchi, Yuki

WEKO 178212

Higuchi, Yuki

Search repository
著者別名
識別子
識別子 178213
識別子Scheme WEKO
姓名
姓名 樋口, 裕樹
抄録
内容記述タイプ Abstract
内容記述 Obesity and related disorders, which are increasing in adults worldwide, are closely linked to childhood diet and are associated with chronic inflammation. Rice endosperm protein (REP) intake during adulthood has been reported to improve lipid metabolism and suppress the progression of diabetic kidney disease in animal models. However, the effects of REP intake during childhood on adulthood health are unclear. Therefore, we used a mouse model to experimentally investigate the preconditioning effects of REP intake during childhood on the development of obesity and related disorders in adulthood. Male C57BL/6J mice were pair-fed a normal-fat diet containing casein or REP during the juvenile period and then a high-fat diet (HFD) containing casein or REP during adulthood. Mice fed REP during the juvenile period showed better body weight, blood pressure, serum lipid profiles, lipopolysaccharide (LPS)-binding protein levels, and glucose tolerance in adulthood than those fed casein during the juvenile period. HFD-induced renal tubulo-glomerular alterations and hepatic microvesicular steatosis were less evident in REP-fed mice than in casein-fed ones. REP intake during the juvenile period improved HFD-induced dysbiosis (i.e., Escherichia genus proliferation and reduced gut microbiota diversity), thereby suppressing endotoxin-related chronic inflammation. Indeed, REP-derived peptides showed antibacterial activity against Escherichia coli, a major producer of LPS. In conclusion, REP supplementation during the juvenile period may regulate the gut microbiota and thus suppress the development of obesity and related disorders in adulthood in mice.
内容記述
内容記述タイプ Other
内容記述 Nutrients. 2019, 11(12), 2919.
DOI
関連識別子
識別子タイプ DOI
関連識別子 info:doi/10.3390/nu11122919
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2020-09-23
学位授与番号
学位授与番号 13101甲第4792号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第962号
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