{"created":"2021-03-01T06:40:31.280967+00:00","id":34068,"links":{},"metadata":{"_buckets":{"deposit":"67fefb60-d1ff-4135-a2a9-5047a9277ddd"},"_deposit":{"id":"34068","owners":[],"pid":{"revision_id":0,"type":"depid","value":"34068"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00034068","sets":["453:456","471:537:538:2010"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Analysis of The Osteoporosis Associated Gene MPP7 in MPP7 General Knockout Mouse"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7-8","bibliographicPageEnd":"291","bibliographicPageStart":"283","bibliographicVolumeNumber":"133","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"骨粗鬆症は骨折のリスク因子であり，生活の質の低下に直結する疾患である．ヒトゲノムワイド関連解析により，membrane palmitoylated protein 7(MPP7)遺伝子が骨密度に関与することが示された. その際，MPP7の発現低下が骨密度の低下と相関した．申請者らは，Mpp7遺伝子の欠損マウスを樹立し，生体内におけるMPP7の機能を解析した．MPP7欠損マウスは野生型マウスと同頻度で生まれた．雌のMPP7欠損マウスは野生型マウスよりも低い体重を示した. この体重の差は，雄のマウスでは観察されなかった. 体重を除いては，Mpp7-KOマウスに特異的な異常は同定できなかった．ヒト細胞株を用いて，MPP7の蛋白の発現を調べたところ，MPP7は複数の骨肉腫由来の細胞株に発現していることが示された．以上の結果は，MPP7が生体内において体重の制御に関与すること，および樹立したMPP7欠損マウスがMPP7による骨密度の制御機構を解析する上で，有用なモデル動物になることを示した．","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"178122","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kijima, Yasufumi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_relation_31":{"attribute_name":"異版である","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10191/51711","subitem_relation_type_select":"URI"}}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木島, 靖文"}],"nameIdentifiers":[{"nameIdentifier":"177871","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-14"}],"displaytype":"detail","filename":"133(7-8)_283-291.pdf","filesize":[{"value":"6.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"133(7-8)_283-291","url":"https://niigata-u.repo.nii.ac.jp/record/34068/files/133(7-8)_283-291.pdf"},"version_id":"3cc4afa1-0a1d-46de-b94e-f5c95664de67"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"MPP7","subitem_subject_scheme":"Other"},{"subitem_subject":"骨粗鬆症","subitem_subject_scheme":"Other"},{"subitem_subject":"DLG1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ノックアウトマウスを用いた骨粗鬆症関連遺伝子MPP7の生体内機能の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ノックアウトマウスを用いた骨粗鬆症関連遺伝子MPP7の生体内機能の解析"}]},"item_type_id":"7","owner":"1","path":["456","2010"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-14"},"publish_date":"2020-09-14","publish_status":"0","recid":"34068","relation_version_is_last":true,"title":["ノックアウトマウスを用いた骨粗鬆症関連遺伝子MPP7の生体内機能の解析"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T04:04:25.574877+00:00"}