{"created":"2021-03-01T06:40:31.147600+00:00","id":34066,"links":{},"metadata":{"_buckets":{"deposit":"8e48b72e-a6db-4fa5-83c1-95e22847990d"},"_deposit":{"id":"34066","owners":[],"pid":{"revision_id":0,"type":"depid","value":"34066"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00034066","sets":["453:456","471:537:538:2010"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Autophagy Regulates Lipid Metabolism Through Selective Turnover of NCoR1 (Relationship between Autophagy and Disease)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7-8","bibliographicPageEnd":"279","bibliographicPageStart":"272","bibliographicVolumeNumber":"133","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"オートファジーは液胞あるいはリソソームにおいて自己成分を分解する経路の総称である．複数あるオートファジー経路のうちオートファゴソーム形成を伴うマクロオートファジーの研究が最も進んでいる．一般にオートファジーは非選択的分解経路と考えられてきたが，マクロオートファジーをはじめ全てのオートファジー経路が可溶性タンパク質，液－液相分離した顆粒，凝集体，核酸さらには細胞小器官をも選択的に認識，隔離，分解することが明らかになり，その生理作用が注目されている．本稿では，哺乳類におけるマクロオートファジーによる選択的基質分解機構を概説し，後半に著者らが最近見出したマクロオートファジーによる可溶性タンパク質NCoR1の選択的分解とその生理作用，つまり脂肪酸異化・同化作用について紹介する．","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"178119","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Komatsu, Masaaki"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小松, 雅明"}],"nameIdentifiers":[{"nameIdentifier":"178118","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-14"}],"displaytype":"detail","filename":"133(7-8)_272-279.pdf","filesize":[{"value":"6.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"133(7-8)_272-279","url":"https://niigata-u.repo.nii.ac.jp/record/34066/files/133(7-8)_272-279.pdf"},"version_id":"02d5f8ee-67e3-4f3e-88a7-8e574be20e80"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"オートファジー","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロオートファジ一","subitem_subject_scheme":"Other"},{"subitem_subject":"β酸化","subitem_subject_scheme":"Other"},{"subitem_subject":"NCoR1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"2 オートファジーによるNCoR1分解 : 脂肪酸合成と分解の調節 (シンポジウム オートファジーと臨床疾患，第735回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2 オートファジーによるNCoR1分解 : 脂肪酸合成と分解の調節 (シンポジウム オートファジーと臨床疾患，第735回新潟医学会)"}]},"item_type_id":"7","owner":"1","path":["456","2010"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-14"},"publish_date":"2020-09-14","publish_status":"0","recid":"34066","relation_version_is_last":true,"title":["2 オートファジーによるNCoR1分解 : 脂肪酸合成と分解の調節 (シンポジウム オートファジーと臨床疾患，第735回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T04:04:08.202760+00:00"}