{"created":"2021-03-01T06:40:28.698911+00:00","id":34030,"links":{},"metadata":{"_buckets":{"deposit":"8360642d-3b34-4dc0-8f48-f586ed6e03dd"},"_deposit":{"id":"34030","owners":[],"pid":{"revision_id":0,"type":"depid","value":"34030"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00034030","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"新規GSK-3β阻害薬である9-ING-41は膀胱癌に対して抗腫瘍効果を発揮する"}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-23"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Glycogen synthase kinase-3 beta (GSK-3β), a serine/threonine kinase, has been identifed as a potential therapeutic target in human bladder cancer. In the present study, we investigated the antitumor effect of a small molecule GSK-3β inhibitor, 9-ING-41, currently in clinical studies in patients with advanced cancer, in bladder cancer cell lines. We found that treatment with 9-ING-41 leads to cell cycle arrest, autophagy and apoptosis in bladder cancer cells. The autophagy inhibitor chloroquine potentiated the antitumor effect of 9-ING-41 when tested in combination studies. Our fndings also demonstrate that9-ING-41 enhanced the growth inhibitory effects of gemcitabine or cisplatin when used in combination in bladder cancer cells. Finally, we found that 9-ING-41 sensitized bladder cancer cells to the cytotoxic effects of human immune effector cells. Our results provide a rationale for the inclusion of patients with advanced bladder cancer in clinical studies of 9-ING-41.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Scientific Reports. 2019, 9, 19977.","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博(医)甲第939号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4705号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"178059","nameIdentifierScheme":"WEKO"}],"names":[{"name":"黒木, 大生"}]}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s41598-019-56461-4","subitem_relation_type_select":"DOI"}}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kuroki, Hiroo"}],"nameIdentifiers":[{"nameIdentifier":"178058","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-31"}],"displaytype":"detail","filename":"r1nmk939.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/34030/files/r1nmk939.pdf"},"version_id":"3b451164-9069-4e4d-8765-1a4d6d9d1c26"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-31"}],"displaytype":"detail","filename":"r1nmk939_a.pdf","filesize":[{"value":"573.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/34030/files/r1nmk939_a.pdf"},"version_id":"4df306ba-ec93-41b6-bf6d-0a295b4e0f48"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the efects of anticancer therapeutics in bladder cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the efects of anticancer therapeutics in bladder cancer"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-31"},"publish_date":"2020-08-31","publish_status":"0","recid":"34030","relation_version_is_last":true,"title":["9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the efects of anticancer therapeutics in bladder cancer"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T04:04:19.465127+00:00"}