@misc{oai:niigata-u.repo.nii.ac.jp:00034030,
 author = {Kuroki, Hiroo},
 month = {2020-08-31, 2020-08-31},
 note = {Glycogen synthase kinase-3 beta (GSK-3β), a serine/threonine kinase, has been identifed as a potential therapeutic target in human bladder cancer. In the present study, we investigated the antitumor effect of a small molecule GSK-3β inhibitor, 9-ING-41, currently in clinical studies in patients with advanced cancer, in bladder cancer cell lines. We found that treatment with 9-ING-41 leads to cell cycle arrest, autophagy and apoptosis in bladder cancer cells. The autophagy inhibitor chloroquine potentiated the antitumor effect of 9-ING-41 when tested in combination studies. Our fndings also demonstrate that9-ING-41 enhanced the growth inhibitory effects of gemcitabine or cisplatin when used in combination in bladder cancer cells. Finally, we found that 9-ING-41 sensitized bladder cancer cells to the cytotoxic effects of human immune effector cells. Our results provide a rationale for the inclusion of patients with advanced bladder cancer in clinical studies of 9-ING-41., Scientific Reports. 2019, 9, 19977., 新大院博(医)甲第939号},
 title = {9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the efects of anticancer therapeutics in bladder cancer},
 year = {}
}