@misc{oai:niigata-u.repo.nii.ac.jp:00034022,
 author = {Anraku, Tsutomu},
 month = {2020-08-31, 2020-08-31},
 note = {Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, is involved in a broad range of pathological　processes including cancer. GSK-3 has two isoforms, GSK-3αand GSK-3β, and GSK-3β has been recognized as a therapeutic target for the development of new anticancer drugs. The present study aimed to investigate the antitumor effects of9-ING-41, which is a maleimide-based ATP-competitive small molecule GSK-3β inhibitor active in patients with advanced cancer. In renal cancer cell lines, treatment with 9-ING-41 alone induced cell cycle arrest and apoptosis, and autophagy inhibitors increased the antitumor effects of 9-ING-41 when used in combination. Treatment with 9-ING-41 potentiated the antitumor effects of targeted therapeutics and increased the cytotoxic effects of cytokine-activated immune cells on renal cancer cell lines. These results provided a compelling rationale for the inclusion of patients with renal cancer in studies of 9-ING-41, both as a single agent and in combination with current standard therapies., International Journal of Molecular Medicine. 2020, 45(2), 315-323., 新大院博(医)甲第931号},
 title = {Clinically relevant GSK‑3β inhibitor 9‑ING‑41 is active as a single agent and in combination with other antitumor therapies in human renal cancer},
 year = {}
}