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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Loss of autophagy impairs physiological steatosis by accumulation of NCoR1

http://hdl.handle.net/10191/00051795
http://hdl.handle.net/10191/00051795
d1acef07-f34f-416b-b766-86a0191a06ad
名前 / ファイル ライセンス アクション
r1nmk906.pdf 本文 (2.4 MB)
r1nmk906_a.pdf 要旨 (571.6 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-08-31
タイトル
タイトル Loss of autophagy impairs physiological steatosis by accumulation of NCoR1
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル オートファジーの機能不全はNCoR1の蓄積により生理的脂肪肝を障害する
著者 Takahashi, Shunsaku

× Takahashi, Shunsaku

WEKO 177993

Takahashi, Shunsaku

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著者別名
識別子 177994
識別子Scheme WEKO
姓名 髙橋, 俊作
抄録
内容記述タイプ Abstract
内容記述 Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, such as after a meal. LDs serve as an energy reservoir during fasting and have a buffering capacity that prevents lipotoxicity. Autophagy and the autophagic machinery have been proposed to play a role in LD biogenesis, but the underlying molecular mechanism remains unclear. Here, we show that when nuclear receptor co-repressor 1 (NCoR1), which inhibits the transactivation of nuclear receptors, accumulates because of autophagy suppression, LDs decrease in size and number. Ablation of ATG7, a gene essential for autophagy, suppressed the expression of gene targets of liver X receptor α, a nuclear receptor responsible for fatty acid and triglyceride synthesis in an NCoR1-dependent manner. LD accumulation in response to fasting and after hepatectomy was hampered by the suppression of autophagy. These results suggest that autophagy controls physiological hepatosteatosis by fine-tuning NCoR1 protein levels.
内容記述
内容記述タイプ Other
内容記述 Life Science Alliance. 2020, 3(1), e201900513.
書誌情報 p. 1-10
DOI
識別子タイプ DOI
関連識別子 info:doi/10.26508/lsa.201900513
権利
権利情報 【○!C】 2019 Takahashi et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2020-03-23
学位授与番号
学位授与番号 13101甲第4672号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第906号
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