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Loss of autophagy impairs physiological steatosis by accumulation of NCoR1
http://hdl.handle.net/10191/00051795
http://hdl.handle.net/10191/00051795d1acef07-f34f-416b-b766-86a0191a06ad
名前 / ファイル | ライセンス | アクション |
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本文 (2.4 MB)
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要旨 (571.6 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-08-31 | |||||
タイトル | ||||||
タイトル | Loss of autophagy impairs physiological steatosis by accumulation of NCoR1 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | オートファジーの機能不全はNCoR1の蓄積により生理的脂肪肝を障害する | |||||
著者 |
Takahashi, Shunsaku
× Takahashi, Shunsaku |
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著者別名 | ||||||
識別子 | 177994 | |||||
識別子Scheme | WEKO | |||||
姓名 | 髙橋, 俊作 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, such as after a meal. LDs serve as an energy reservoir during fasting and have a buffering capacity that prevents lipotoxicity. Autophagy and the autophagic machinery have been proposed to play a role in LD biogenesis, but the underlying molecular mechanism remains unclear. Here, we show that when nuclear receptor co-repressor 1 (NCoR1), which inhibits the transactivation of nuclear receptors, accumulates because of autophagy suppression, LDs decrease in size and number. Ablation of ATG7, a gene essential for autophagy, suppressed the expression of gene targets of liver X receptor α, a nuclear receptor responsible for fatty acid and triglyceride synthesis in an NCoR1-dependent manner. LD accumulation in response to fasting and after hepatectomy was hampered by the suppression of autophagy. These results suggest that autophagy controls physiological hepatosteatosis by fine-tuning NCoR1 protein levels. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Life Science Alliance. 2020, 3(1), e201900513. | |||||
書誌情報 | p. 1-10 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.26508/lsa.201900513 | |||||
権利 | ||||||
権利情報 | 【○!C】 2019 Takahashi et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2020-03-23 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4672号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第906号 |