{"created":"2021-03-01T06:40:21.550688+00:00","id":33925,"links":{},"metadata":{"_buckets":{"deposit":"78b42cbc-0448-4d68-91d4-b235b63d1faa"},"_deposit":{"id":"33925","owners":[],"pid":{"revision_id":0,"type":"depid","value":"33925"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00033925"},"item_6_alternative_title_1":{"attribute_name":"\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_alternative_title":"USP10\u306fTau\u967d\u6027\u306e\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306e\u5f62\u6210\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059"}]},"item_6_date_granted_51":{"attribute_name":"\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5","attribute_value_mlt":[{"subitem_dategranted":"2019-09-20"}]},"item_6_degree_grantor_49":{"attribute_name":"\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"\u65b0\u6f5f\u5927\u5b66"}]}]},"item_6_degree_name_48":{"attribute_name":"\u5b66\u4f4d\u540d","attribute_value_mlt":[{"subitem_degreename":"\u535a\u58eb(\u533b\u5b66)"}]},"item_6_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"Tau aggregates in neurons of brain lesions is a hallmark pathology of tauopathies, including Alzheimer\u2019s disease (AD). Recent studies suggest that the RNA-binding protein TIA1 initiates Tau aggregation by inducing the formation of stress granules (SGs) containing Tau. SGs are stress-inducible cytoplasmic protein aggregates containing many RNA-binding proteins that has been implicated as an initial site of multiple pathogenic protein aggregates in several neurodegenerative diseases. In this study, we found that ubiquitin-specific protease 10 (USP10) is a critical factor for the formation of Tau/TIA1/USP10-positive SGs. Proteasome inhibition or TIA1-overexpression in HT22 neuronal cells induced the formation of TIA1/Tau-positive SGs, and the formations were severely attenuated by depletion of USP10. In addition, the overexpression of USP10 without stress stimuli in HT22 cells induced TIA1/Tau/USP10-positive SGs in a deubiquitinase-independent manner. In AD brain lesions, USP10 was colocalized with Tau aggregates in the cell body of neurons. The present findings suggest that USP10 plays a key role in the initiation of pathogenic Tau aggregation in AD through SG formation.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"\u5185\u5bb9\u8a18\u8ff0","attribute_value_mlt":[{"subitem_description":"Scientific Reports. 2019, 9(1), 10591","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"\u5b66\u4f4d\u8a18\u756a\u53f7","attribute_value_mlt":[{"subitem_description":"\u65b0\u5927\u9662\u535a(\u533b)\u7532\u7b2c902\u53f7","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7","attribute_value_mlt":[{"subitem_dissertationnumber":"13101\u7532\u7b2c4642\u53f7"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s41598-019-47033-7","subitem_relation_type_select":"DOI"}}]},"item_6_select_19":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Piatnitskaia, Svetlana"}],"nameIdentifiers":[{"nameIdentifier":"177892","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-08"}],"displaytype":"detail","filename":"r1nmk902.pdf","filesize":[{"value":"10.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"\u672c\u6587","url":"https://niigata-u.repo.nii.ac.jp/record/33925/files/r1nmk902.pdf"},"version_id":"75e6d531-e02a-45ed-b6d3-bf4e537d3791"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-08"}],"displaytype":"detail","filename":"r1nmk902_a.pdf","filesize":[{"value":"681.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"\u8981\u65e8","url":"https://niigata-u.repo.nii.ac.jp/record/33925/files/r1nmk902_a.pdf"},"version_id":"52a971d0-0b5f-42e6-988a-83c811e5fc78"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells"}]},"item_type_id":"6","owner":"1","path":["453/455","471/561/562"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2020-07-08"},"publish_date":"2020-07-08","publish_status":"0","recid":"33925","relation_version_is_last":true,"title":["USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T08:08:47.870150+00:00"}