{"_buckets": {"deposit": "78b42cbc-0448-4d68-91d4-b235b63d1faa"}, "_deposit": {"id": "33925", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "33925"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00033925", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "USP10はTau陽性のストレス顆粒の形成に重要な役割を果たす"}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2019-09-20"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Tau aggregates in neurons of brain lesions is a hallmark pathology of tauopathies, including Alzheimer’s disease (AD). Recent studies suggest that the RNA-binding protein TIA1 initiates Tau aggregation by inducing the formation of stress granules (SGs) containing Tau. SGs are stress-inducible cytoplasmic protein aggregates containing many RNA-binding proteins that has been implicated as an initial site of multiple pathogenic protein aggregates in several neurodegenerative diseases. In this study, we found that ubiquitin-specific protease 10 (USP10) is a critical factor for the formation of Tau/TIA1/USP10-positive SGs. Proteasome inhibition or TIA1-overexpression in HT22 neuronal cells induced the formation of TIA1/Tau-positive SGs, and the formations were severely attenuated by depletion of USP10. In addition, the overexpression of USP10 without stress stimuli in HT22 cells induced TIA1/Tau/USP10-positive SGs in a deubiquitinase-independent manner. In AD brain lesions, USP10 was colocalized with Tau aggregates in the cell body of neurons. The present findings suggest that USP10 plays a key role in the initiation of pathogenic Tau aggregation in AD through SG formation.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Scientific Reports. 2019, 9(1), 10591", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(医)甲第902号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4642号"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1038/s41598-019-47033-7", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Piatnitskaia, Svetlana"}], "nameIdentifiers": [{"nameIdentifier": "177892", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-07-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r1nmk902.pdf", "filesize": [{"value": "10.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 10700000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/33925/files/r1nmk902.pdf"}, "version_id": "75e6d531-e02a-45ed-b6d3-bf4e537d3791"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-07-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r1nmk902_a.pdf", "filesize": [{"value": "681.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 681300.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/33925/files/r1nmk902_a.pdf"}, "version_id": "52a971d0-0b5f-42e6-988a-83c811e5fc78"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/00051723", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-07-08"}, "publish_date": "2020-07-08", "publish_status": "0", "recid": "33925", "relation": {}, "relation_version_is_last": true, "title": ["USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells"], "weko_shared_id": null}