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Mechanisms of noradrenergic modulation of synaptic transmission and neuronal excitability in ventral horn neurons of the rat spinal cord
http://hdl.handle.net/10191/00051716
http://hdl.handle.net/10191/00051716b930f9c2-5380-4545-9f80-a35622a96312
| 名前 / ファイル | ライセンス | アクション |
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本文 (2.7 MB)
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要旨 (448.6 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2020-07-08 | |||||
| タイトル | ||||||
| タイトル | Mechanisms of noradrenergic modulation of synaptic transmission and neuronal excitability in ventral horn neurons of the rat spinal cord | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | monoamine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | adrenoceptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ventral horn neuron | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | spinal cord injury | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | patch clamp | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 脊髄前角運動ニューロンのシナプス伝達および細胞興奮性に対するノルアドレナリンの作用機序 | |||||
| 著者 |
Shoji, Hirokazu
× Shoji, Hirokazu |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 177881 | |||||
| 姓名 | 庄司, 寛和 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Noradrenaline (NA) modulates the spinal motor networks for locomotion and facilitates neuroplasticity, possibly assisting neuronal network activation and neuroplasticity in the recovery phase of spinal cord injuries. However, neither the effects nor the mechanisms of NA on synaptic transmission and neuronal excitability in spinal ventral horn (VH) neurons are well characterized, especially in rats aged 7 postnatal days or older. To gain insight into NA regulation of VH neuronal activity, we used a whole-cell patch-clamp approach in late neonatal rats (postnatal day 7–15). In voltage-clamp recordings at −70 mV, NA increased the frequency and amplitude of excitatory postsynaptic currents via the activation of somatic α_1- and β-adrenoceptors of presynaptic neurons. Moreover, NA induced an inward current through the activation of postsynapticα_1- and β-adrenoceptors. At a holding potential of 0 mV, NA also increased frequency and amplitude of both GABAergic and glycinergic inhibitory postsynaptic currents via the activation of somatic adrenoceptors in presynaptic neurons. In current-clamp recordings, NA depolarized resting membrane potentials and increased the firing frequency of action potentials in VH neurons, indicating that it enhances the excitability of these neurons. Our findings provide new insights that establish NA-based pharmacological therapy as an effective method to activate neuronal networks of the spinal VH in the recovery phase of spinal cord injuries. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Neuroscience. 2019, 408, 161-176. | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.neuroscience.2019.03.026 | |||||
| 権利 | ||||||
| 権利情報 | 【○!C】 2019 IBRO. Published by Elsevier Ltd. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2019-09-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4635号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博(医)甲第895号 | |||||
