{"created":"2021-03-01T06:40:20.740702+00:00","id":33913,"links":{},"metadata":{"_buckets":{"deposit":"82988f85-3fe0-49aa-abc0-ce6d07d180f1"},"_deposit":{"id":"33913","owners":[],"pid":{"revision_id":0,"type":"depid","value":"33913"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00033913","sets":["453:455","471:561:562"]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-09-20"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"骨粗鬆症は骨折のリスク因子であり、生活の質の低下に直結する疾患である。ヒトゲノムワイド関連解析により、membrane palmitoylated protein 7(MPP7)遺伝子が骨密度に関与することが示された。その際、MPP7の発現低下が骨密度の低下と相関した。申請者らは、Mpp7遺伝子の欠損マウスを樹立し、生体内におけるMPP7の機能を解析した。MPP7欠損マウスは野生型マウスと同頻度で生まれた。雌のMPP7欠損マウスは野生型マウスよりも低い体重を示した。この体重の差は、雄のマウスでは観察されなかった。体重を除いては、Mpp7-KOマウスに特異的な異常は同定できなかった。ヒト細胞株を用いて、MPP7の蛋白の発現を調べたところ、MPP7は複数の骨肉腫由来の細胞株に発現していることが示された。以上の結果は、MPP7が生体内において体重の制御に関与すること、および樹立したMPP7欠損マウスがMPP7による骨密度の制御機構を解析する上で、有用なモデル動物になることを示した。","subitem_description_type":"Abstract"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博(医)甲第890号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4630号"}]},"item_6_relation_32":{"attribute_name":"異版あり","attribute_value_mlt":[{"subitem_relation_type":"hasVersion","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10191/51866","subitem_relation_type_select":"URI"}}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木島, 靖文"}],"nameIdentifiers":[{"nameIdentifier":"177871","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-08"}],"displaytype":"detail","filename":"r1nmk890.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/33913/files/r1nmk890.pdf"},"version_id":"45d82482-1d26-4ae6-b775-aad3e2e81524"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-08"}],"displaytype":"detail","filename":"r1nmk890_a.pdf","filesize":[{"value":"738.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/33913/files/r1nmk890_a.pdf"},"version_id":"961318b2-ca96-440d-a9b3-48f1f71dced1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"MPP7","subitem_subject_scheme":"Other"},{"subitem_subject":"骨粗鬆症","subitem_subject_scheme":"Other"},{"subitem_subject":"DLG1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"ノックアウトマウスを用いた骨粗鬆症関連遺伝子MPP7の生体内機能の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ノックアウトマウスを用いた骨粗鬆症関連遺伝子MPP7の生体内機能の解析"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-08"},"publish_date":"2020-07-08","publish_status":"0","recid":"33913","relation_version_is_last":true,"title":["ノックアウトマウスを用いた骨粗鬆症関連遺伝子MPP7の生体内機能の解析"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T04:04:08.606502+00:00"}