{"created":"2021-03-01T06:40:09.750332+00:00","id":33727,"links":{},"metadata":{"_buckets":{"deposit":"6479ec9a-7c08-4175-9546-99db4ae585cb"},"_deposit":{"id":"33727","owners":[],"pid":{"revision_id":0,"type":"depid","value":"33727"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00033727","sets":["453:456","471:537:538:1992"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Gene Therapy for Dominant Negative Disorders"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8-9","bibliographicPageEnd":"292","bibliographicPageStart":"289","bibliographicVolumeNumber":"132","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌 "},{"bibliographic_title":"NIIGATA MEDICAL JOURNAL","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"表皮水疱症は先天的に皮膚が脆弱で，軽微な外力により容易に水疱やびらんを生じる疾患である．表皮―真皮接着部の構成タンパクをコードする遺伝子の変異によって生じることが知られている．我々は表皮水疱症に対し，CRISPR/Cas9システムを用いた遺伝子治療および患者由来のiPS細胞や表皮角化細胞を用いた再生医療の開発を行っている．今回，我々の研究成果を中心に，表皮水疱症の最新治療戦略について概説する．","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"177719","nameIdentifierScheme":"WEKO"}],"names":[{"name":"SHINKUMA, Satoru"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"新熊, 悟"}],"nameIdentifiers":[{"nameIdentifier":"177718","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","displaytype":"detail","filename":"132(8-9)_289-292.pdf","filesize":[{"value":"3.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://niigata-u.repo.nii.ac.jp/record/33727/files/132(8-9)_289-292.pdf"},"version_id":"deb918b4-b260-48a7-8a94-99480ce43bac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"表皮水疱症","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子治療","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子編集","subitem_subject_scheme":"Other"},{"subitem_subject":"iPS細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"表皮水疱症の新規治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"表皮水疱症の新規治療法の開発"},{"subitem_title":"Gene Therapy for Dominant Negative Disorders","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1992"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-09"},"publish_date":"2020-04-09","publish_status":"0","recid":"33727","relation_version_is_last":true,"title":["表皮水疱症の新規治療法の開発"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T04:03:39.815318+00:00"}