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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia

http://hdl.handle.net/10191/51317
http://hdl.handle.net/10191/51317
9bc81f15-9af2-4c3b-af32-3715acfa8926
名前 / ファイル ライセンス アクション
h30nmk858.pdf 本文 (1.7 MB)
h30nmk858_a.pdf 要旨 (790.9 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-07-09
タイトル
タイトル Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia
タイトル
言語 en
タイトル Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 統合失調症患者死後脳海馬におけるコンドロイチン硫酸部位の病理学的変化
著者 Yukawa, Takayuki

× Yukawa, Takayuki

WEKO 175160

Yukawa, Takayuki

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著者別名
識別子 175161
識別子Scheme WEKO
姓名 湯川, 尊行
抄録
内容記述タイプ Abstract
内容記述 Perineuronal nets comprise chondroitin sulfate moieties and their core proteins, and their neuropathological alterations have been implicated in schizophrenia. To explore the molecular mechanism of the perineuronal net impairments in schizophrenia, we measured the immunoreactivity of chondroitin sulfate moieties, major components of perineuronal nets, in three brain regions (postmortem dorsolateral prefrontal cortex, caudate nucleus, and hippocampus) of schizophrenia patients and control subjects. Immunoblotting for chondroitin 4-sulfate and chondroitin 6-sulfate moieties revealed a significant increase in intensity of a 180 kD band of chondroitin 4- sulfate immunoreactivity in the hippocampus of patients, although we detected no significant alteration in their immunoreactivities with any other molecular sizes or in other brain regions. The levels of immunoreactivity were not correlated with postmortem interval, age, or storage time. We failed to find such an increase in a similar molecular range of the chondroitin 4-sulfate immunoreactivity in the hippocampus of the rats chronically treated with haloperidol. These results suggest that the level alteration of the chondroitin 4-sulfate moiety might contribute to the perineuronal net abnormality found in patients with schizophrenia.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4536号. 学位記番号: 新大院博(医)甲第858号. 学位授与年月日: 平成31年3月25日
書誌情報 発行日 2019-03-25
出版者
出版者 新潟大学
権利
権利情報 【○!C】2018 Elsevier B.V. All rights reserved.
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2019-03-25
学位授与番号
学位授与番号 13101甲第4536号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第858号
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