{"created":"2021-03-01T06:38:18.126207+00:00","id":32054,"links":{},"metadata":{"_buckets":{"deposit":"bdbdb665-9e35-4fd9-8ad5-ce58bdf49521"},"_deposit":{"id":"32054","owners":[],"pid":{"revision_id":0,"type":"depid","value":"32054"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00032054","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"子宮内膜症と正常子宮内膜における癌関連遺伝子変異のクローン性増殖と多様性"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-03-25"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Endometriosis is characterized by ectopic endometrial- like epithelium and stroma, of which molecular characteristics remain to be fully elucidated. We sequenced 107 ovarian endometriotic and 82 normal uterine endometrial epithelium samples isolated by laser microdissection. In both endometriotic and normal epithelium samples, numerous somatic mutations were identified within genes frequently mutated in endometriosis-associated ovarian cancers. KRAS is frequently mutated in endometriotic epithelium, with a higher mutant allele frequency (MAF) accompanied by arm-level allelic imbalances. Analyses of MAF, combined with multiregional sequencing, illuminated spatiotemporal evolution of the endometriosis and uterine endometrium genomes. We sequenced 109 single endometrial glands and found that each gland carried distinct cancer-associated mutations, demonstrating the heterogeneity of the genomic architecture of endometrial epithelium. Remarkable increases in MAF of mutations in cancer-associated genes in endometriotic epithelium suggest retrograde flow of endometrial cells already harboring cancer-associatedmutations, with selective advantages at ectopic sites, leading to the development of endometriosis.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（医学）. 報告番号: 甲第4519号. 学位記番号: 新大院博（医）甲第841号. 学位授与年月日: 平成31年3月25日","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（医）甲第841号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4519号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"175128","nameIdentifierScheme":"WEKO"}],"names":[{"name":"須田, 一暁"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"【○!C】2018 The Author(s)"}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suda, Kazuaki"}],"nameIdentifiers":[{"nameIdentifier":"175127","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-19"}],"displaytype":"detail","filename":"h30nmk841.pdf","filesize":[{"value":"5.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/32054/files/h30nmk841.pdf"},"version_id":"76721cb6-a5d8-4ec4-bcae-60c69e43528e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-10"}],"displaytype":"detail","filename":"h30nmk841_a.pdf","filesize":[{"value":"792.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/32054/files/h30nmk841_a.pdf"},"version_id":"7f0d57a6-4bd8-45bc-bc7b-c18f7e2f6f52"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium"},{"subitem_title":"Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-09"},"publish_date":"2019-07-09","publish_status":"0","recid":"32054","relation_version_is_last":true,"title":["Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T04:02:23.620400+00:00"}