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Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium
http://hdl.handle.net/10191/51314
http://hdl.handle.net/10191/51314af374f1e-b464-4cb2-8f80-58a93b453e9a
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2019-07-09 | |||||
タイトル | ||||||
タイトル | Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | 子宮内膜症と正常子宮内膜における癌関連遺伝子変異のクローン性増殖と多様性 | |||||
著者 |
Suda, Kazuaki
× Suda, Kazuaki |
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著者別名 | ||||||
識別子 | 175128 | |||||
識別子Scheme | WEKO | |||||
姓名 | 須田, 一暁 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Endometriosis is characterized by ectopic endometrial- like epithelium and stroma, of which molecular characteristics remain to be fully elucidated. We sequenced 107 ovarian endometriotic and 82 normal uterine endometrial epithelium samples isolated by laser microdissection. In both endometriotic and normal epithelium samples, numerous somatic mutations were identified within genes frequently mutated in endometriosis-associated ovarian cancers. KRAS is frequently mutated in endometriotic epithelium, with a higher mutant allele frequency (MAF) accompanied by arm-level allelic imbalances. Analyses of MAF, combined with multiregional sequencing, illuminated spatiotemporal evolution of the endometriosis and uterine endometrium genomes. We sequenced 109 single endometrial glands and found that each gland carried distinct cancer-associated mutations, demonstrating the heterogeneity of the genomic architecture of endometrial epithelium. Remarkable increases in MAF of mutations in cancer-associated genes in endometriotic epithelium suggest retrograde flow of endometrial cells already harboring cancer-associatedmutations, with selective advantages at ectopic sites, leading to the development of endometriosis. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学位の種類: 博士(医学). 報告番号: 甲第4519号. 学位記番号: 新大院博(医)甲第841号. 学位授与年月日: 平成31年3月25日 | |||||
書誌情報 | 発行日 2019-03-25 | |||||
出版者 | ||||||
出版者 | 新潟大学 | |||||
権利 | ||||||
権利情報 | 【○!C】2018 The Author(s) | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2019-03-25 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4519号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第841号 |