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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium

http://hdl.handle.net/10191/51314
http://hdl.handle.net/10191/51314
af374f1e-b464-4cb2-8f80-58a93b453e9a
名前 / ファイル ライセンス アクション
h30nmk841.pdf 本文 (5.7 MB)
h30nmk841_a.pdf 要旨 (792.2 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-07-09
タイトル
タイトル Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium
タイトル
言語 en
タイトル Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 子宮内膜症と正常子宮内膜における癌関連遺伝子変異のクローン性増殖と多様性
著者 Suda, Kazuaki

× Suda, Kazuaki

WEKO 175127

Suda, Kazuaki

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著者別名
識別子 175128
識別子Scheme WEKO
姓名 須田, 一暁
抄録
内容記述タイプ Abstract
内容記述 Endometriosis is characterized by ectopic endometrial- like epithelium and stroma, of which molecular characteristics remain to be fully elucidated. We sequenced 107 ovarian endometriotic and 82 normal uterine endometrial epithelium samples isolated by laser microdissection. In both endometriotic and normal epithelium samples, numerous somatic mutations were identified within genes frequently mutated in endometriosis-associated ovarian cancers. KRAS is frequently mutated in endometriotic epithelium, with a higher mutant allele frequency (MAF) accompanied by arm-level allelic imbalances. Analyses of MAF, combined with multiregional sequencing, illuminated spatiotemporal evolution of the endometriosis and uterine endometrium genomes. We sequenced 109 single endometrial glands and found that each gland carried distinct cancer-associated mutations, demonstrating the heterogeneity of the genomic architecture of endometrial epithelium. Remarkable increases in MAF of mutations in cancer-associated genes in endometriotic epithelium suggest retrograde flow of endometrial cells already harboring cancer-associatedmutations, with selective advantages at ectopic sites, leading to the development of endometriosis.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4519号. 学位記番号: 新大院博(医)甲第841号. 学位授与年月日: 平成31年3月25日
書誌情報 発行日 2019-03-25
出版者
出版者 新潟大学
権利
権利情報 【○!C】2018 The Author(s)
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2019-03-25
学位授与番号
学位授与番号 13101甲第4519号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第841号
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