{"created":"2021-03-01T06:38:17.531562+00:00","id":32045,"links":{},"metadata":{"_buckets":{"deposit":"9356a79f-ea4f-4d6e-968a-1661e03e8909"},"_deposit":{"id":"32045","owners":[],"pid":{"revision_id":0,"type":"depid","value":"32045"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00032045","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"二次リンパ器官の間質細胞サブセット発生においてNF-_κB古典的経路活性化が果たす必須の役割"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03-15","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-03-15"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Organized tissue structure in the secondary lymphoid organs (SLOs) tightly depends on the development of fibroblastic stromal cells (FSCs) of mesenchymal origin; however, the mechanisms of this relationship are poorly understood. In this study, we specifically inactivated the canonical NF-kB pathway in FSCs in vivo by conditionally inducing IkBa mutant in a Ccl19-IkBSR mouse system in which NF-kB activity is likely to be suppressed in fetal FSC progenitors. Given that NF-kB activation in fetal FSCs is essential for SLO development, the animals were expected to lack SLOs. However, all SLOs were preserved in Ccl19-IkBSR mice. Instead, the T cell area was severely disturbed by the lack of CCL21-expressing FSCs, whereas the follicles and associated FSC networks were formed. Fate mapping revealed that IkBSR-expressing cells constituted only a small fraction of stromal compartment outside the follicles. Taken together, our findings indicate an essential role of the canonical NF-kB pathway activity in the development of three FSC subsets common to SLOs and suggest transient or stochastic CCL19 expression in FSC progenitors and a compensatory differentiation program of follicular FSCs.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（医学）. 報告番号: 乙第2229号. 学位記番号: 新大博（医）乙第1801号. 学位授与年月日: 平成31年3月15日","subitem_description_type":"Other"},{"subitem_description":"The Journal of immunology. 2018, 201(12), 3580-3586.","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大博（医）乙第1801号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101乙第2229号"}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.4049/jimmunol.1800539","subitem_relation_type_select":"DOI"}}]},"item_6_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 【○!C】 2018 by The American Association of Immunologists Inc."}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bogdanova, Dana"}],"nameIdentifiers":[{"nameIdentifier":"175110","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-10"}],"displaytype":"detail","filename":"h30nmo1801.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/32045/files/h30nmo1801.pdf"},"version_id":"6d69e483-570a-49ce-9910-549ec1805f4b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-10"}],"displaytype":"detail","filename":"h30nmo1801_a.pdf","filesize":[{"value":"530.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/32045/files/h30nmo1801_a.pdf"},"version_id":"24448354-c088-45d4-8e05-de876ce93efe"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs"},{"subitem_title":"Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-09"},"publish_date":"2019-07-09","publish_status":"0","recid":"32045","relation_version_is_last":true,"title":["Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T04:02:23.337711+00:00"}