@misc{oai:niigata-u.repo.nii.ac.jp:00032045,
 author = {Bogdanova, Dana},
 month = {Mar},
 note = {Organized tissue structure in the secondary lymphoid organs (SLOs) tightly depends on the development of fibroblastic stromal cells (FSCs) of mesenchymal origin; however, the mechanisms of this relationship are poorly understood. In this study, we specifically inactivated the canonical NF-kB pathway in FSCs in vivo by conditionally inducing IkBa mutant in a Ccl19-IkBSR mouse system in which NF-kB activity is likely to be suppressed in fetal FSC progenitors. Given that NF-kB activation in fetal FSCs is essential for SLO development, the animals were expected to lack SLOs. However, all SLOs were preserved in Ccl19-IkBSR mice. Instead, the T cell area was severely disturbed by the lack of CCL21-expressing FSCs, whereas the follicles and associated FSC networks were formed. Fate mapping revealed that IkBSR-expressing cells constituted only a small fraction of stromal compartment outside the follicles. Taken together, our findings indicate an essential role of the canonical NF-kB pathway activity in the development of three FSC subsets common to SLOs and suggest transient or stochastic CCL19 expression in FSC progenitors and a compensatory differentiation program of follicular FSCs., 学位の種類: 博士（医学）. 報告番号: 乙第2229号. 学位記番号: 新大博（医）乙第1801号. 学位授与年月日: 平成31年3月15日, The Journal of immunology. 2018, 201(12), 3580-3586., 新大博（医）乙第1801号},
 title = {Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs},
 year = {2019}
}