WEKO3
アイテム
{"_buckets": {"deposit": "9356a79f-ea4f-4d6e-968a-1661e03e8909"}, "_deposit": {"id": "32045", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "32045"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00032045", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "二次リンパ器官の間質細胞サブセット発生においてNF-_κB古典的経路活性化が果たす必須の役割"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-03-15", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "7", "bibliographicPageStart": "1", "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2019-03-15"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Organized tissue structure in the secondary lymphoid organs (SLOs) tightly depends on the development of fibroblastic stromal cells (FSCs) of mesenchymal origin; however, the mechanisms of this relationship are poorly understood. In this study, we specifically inactivated the canonical NF-kB pathway in FSCs in vivo by conditionally inducing IkBa mutant in a Ccl19-IkBSR mouse system in which NF-kB activity is likely to be suppressed in fetal FSC progenitors. Given that NF-kB activation in fetal FSCs is essential for SLO development, the animals were expected to lack SLOs. However, all SLOs were preserved in Ccl19-IkBSR mice. Instead, the T cell area was severely disturbed by the lack of CCL21-expressing FSCs, whereas the follicles and associated FSC networks were formed. Fate mapping revealed that IkBSR-expressing cells constituted only a small fraction of stromal compartment outside the follicles. Taken together, our findings indicate an essential role of the canonical NF-kB pathway activity in the development of three FSC subsets common to SLOs and suggest transient or stochastic CCL19 expression in FSC progenitors and a compensatory differentiation program of follicular FSCs.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "学位の種類: 博士(医学). 報告番号: 乙第2229号. 学位記番号: 新大博(医)乙第1801号. 学位授与年月日: 平成31年3月15日", "subitem_description_type": "Other"}, {"subitem_description": "The Journal of immunology. 2018, 201(12), 3580-3586.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大博(医)乙第1801号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101乙第2229号"}]}, "item_6_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟大学"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.4049/jimmunol.1800539", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright 【○!C】 2018 by The American Association of Immunologists Inc."}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Bogdanova, Dana"}], "nameIdentifiers": [{"nameIdentifier": "175110", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h30nmo1801.pdf", "filesize": [{"value": "2.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2800000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/32045/files/h30nmo1801.pdf"}, "version_id": "6d69e483-570a-49ce-9910-549ec1805f4b"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h30nmo1801_a.pdf", "filesize": [{"value": "530.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 530300.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/32045/files/h30nmo1801_a.pdf"}, "version_id": "24448354-c088-45d4-8e05-de876ce93efe"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs"}, {"subitem_title": "Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/51277", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-07-09"}, "publish_date": "2019-07-09", "publish_status": "0", "recid": "32045", "relation": {}, "relation_version_is_last": true, "title": ["Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs"], "weko_shared_id": 2}
Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs
http://hdl.handle.net/10191/51277
http://hdl.handle.net/10191/512771f7fee92-bcee-404d-b086-bb993dedcf5c
名前 / ファイル | ライセンス | アクション |
---|---|---|
本文 (2.8 MB)
|
|
|
要旨 (530.3 kB)
|
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-07-09 | |||||
タイトル | ||||||
タイトル | Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | 二次リンパ器官の間質細胞サブセット発生においてNF-_κB古典的経路活性化が果たす必須の役割 | |||||
著者 |
Bogdanova, Dana
× Bogdanova, Dana |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Organized tissue structure in the secondary lymphoid organs (SLOs) tightly depends on the development of fibroblastic stromal cells (FSCs) of mesenchymal origin; however, the mechanisms of this relationship are poorly understood. In this study, we specifically inactivated the canonical NF-kB pathway in FSCs in vivo by conditionally inducing IkBa mutant in a Ccl19-IkBSR mouse system in which NF-kB activity is likely to be suppressed in fetal FSC progenitors. Given that NF-kB activation in fetal FSCs is essential for SLO development, the animals were expected to lack SLOs. However, all SLOs were preserved in Ccl19-IkBSR mice. Instead, the T cell area was severely disturbed by the lack of CCL21-expressing FSCs, whereas the follicles and associated FSC networks were formed. Fate mapping revealed that IkBSR-expressing cells constituted only a small fraction of stromal compartment outside the follicles. Taken together, our findings indicate an essential role of the canonical NF-kB pathway activity in the development of three FSC subsets common to SLOs and suggest transient or stochastic CCL19 expression in FSC progenitors and a compensatory differentiation program of follicular FSCs. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学位の種類: 博士(医学). 報告番号: 乙第2229号. 学位記番号: 新大博(医)乙第1801号. 学位授与年月日: 平成31年3月15日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of immunology. 2018, 201(12), 3580-3586. | |||||
書誌情報 | p. 1-7, 発行日 2019-03-15 | |||||
出版者 | ||||||
出版者 | 新潟大学 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.4049/jimmunol.1800539 | |||||
権利 | ||||||
権利情報 | Copyright 【○!C】 2018 by The American Association of Immunologists Inc. | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2019-03-15 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101乙第2229号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大博(医)乙第1801号 |