ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "ee8b0898-cb32-4d27-a24c-850651058f3e"}, "_deposit": {"id": "32025", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "32025"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00032025", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "セラミド濃度はヒト乳癌組織において上昇し、セラミド濃度と腫瘍増殖とは負の関連を有する"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-09-20", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2018-09-20"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Sphingolipids have emerged as key regulatory molecules in cancer cell survival and death. Although important roles of sphingolipids in breast cancer progression have been reported in experimental models, their roles in human patients are yet to be revealed. The aim of this study was to investigate the ceramide levels and its biosynthesis pathways in human breast cancer patients. Breast cancer, peri-tumor and normal breast tissue samples were collected from surgical specimens from a series of 44 patients with breast cancer. The amount of sphingolipid metabolites in the tissue were determined by mass spectrometry. The Cancer Genome Atlas was used to analyze gene expression related to the sphingolipid metabolism. Ceramide levels were higher in breast cancer tissue compared to both normal and peri-tumor breast tissue. Substrates and enzymes that generate ceramide were significantly increased in all three ceramide biosynthesis pathways in cancer. Further, higher levels of ceramide in breast cancer were associated with less aggressive cancer biology presented by Ki-67 index and nuclear grade of the cancer. Interestingly, patients with higher gene expressions of enzymes in the three major ceramide synthesis pathways showed significantly worse prognosis. This is the first study to reveal the clinical relevance of ceramide metabolism in breast cancer patients. We demonstrated that ceramide levels in breast cancer tissue were significantly higher than those in normal tissue, with activation of the three ceramide biosynthesis pathways. We also identified that ceramide levels have a significant association with aggressive phenotype and its enzymes have prognostic impact on breast cancer patients.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "学位の種類: 博士(医学). 報告番号: 甲第4499号. 学位記番号: 新大院博(医)甲第836号. 学位授与年月日: 平成30年9月20日", "subitem_description_type": "Other"}, {"subitem_description": "Oncotarget. 2018, 9(28), 19874-19890.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(医)甲第836号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4499号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "175084", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "諸, 和樹"}]}]}, "item_6_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟大学"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.18632/oncotarget.24903", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Moro, Kazuki"}], "nameIdentifiers": [{"nameIdentifier": "175083", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h30nmk836.pdf", "filesize": [{"value": "4.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4400000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/32025/files/h30nmk836.pdf"}, "version_id": "e95be84c-53ce-4624-9027-200cd77154be"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h30nmk836_a.pdf", "filesize": [{"value": "441.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 441700.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/32025/files/h30nmk836_a.pdf"}, "version_id": "5d9df1c2-1269-40ad-842d-55ee3c94db03"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "breast cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ceramide", "subitem_subject_scheme": "Other"}, {"subitem_subject": "metabolism", "subitem_subject_scheme": "Other"}, {"subitem_subject": "prognosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "sphingolipid", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Ceramide species are elevated in human breast cancer and are associated with less aggressiveness", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Ceramide species are elevated in human breast cancer and are associated with less aggressiveness"}, {"subitem_title": "Ceramide species are elevated in human breast cancer and are associated with less aggressiveness", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/50772", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-11-29"}, "publish_date": "2018-11-29", "publish_status": "0", "recid": "32025", "relation": {}, "relation_version_is_last": true, "title": ["Ceramide species are elevated in human breast cancer and are associated with less aggressiveness"], "weko_shared_id": 2}
  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Ceramide species are elevated in human breast cancer and are associated with less aggressiveness

http://hdl.handle.net/10191/50772
http://hdl.handle.net/10191/50772
1762a581-63e3-43ce-b2b2-976c209923b3
名前 / ファイル ライセンス アクション
h30nmk836.pdf 本文 (4.4 MB)
h30nmk836_a.pdf 要旨 (441.7 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-11-29
タイトル
タイトル Ceramide species are elevated in human breast cancer and are associated with less aggressiveness
タイトル
言語 en
タイトル Ceramide species are elevated in human breast cancer and are associated with less aggressiveness
言語
言語 eng
キーワード
主題Scheme Other
主題 breast cancer
キーワード
主題Scheme Other
主題 ceramide
キーワード
主題Scheme Other
主題 metabolism
キーワード
主題Scheme Other
主題 prognosis
キーワード
主題Scheme Other
主題 sphingolipid
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル セラミド濃度はヒト乳癌組織において上昇し、セラミド濃度と腫瘍増殖とは負の関連を有する
著者 Moro, Kazuki

× Moro, Kazuki

WEKO 175083

Moro, Kazuki

Search repository
著者別名
識別子 175084
識別子Scheme WEKO
姓名 諸, 和樹
抄録
内容記述タイプ Abstract
内容記述 Sphingolipids have emerged as key regulatory molecules in cancer cell survival and death. Although important roles of sphingolipids in breast cancer progression have been reported in experimental models, their roles in human patients are yet to be revealed. The aim of this study was to investigate the ceramide levels and its biosynthesis pathways in human breast cancer patients. Breast cancer, peri-tumor and normal breast tissue samples were collected from surgical specimens from a series of 44 patients with breast cancer. The amount of sphingolipid metabolites in the tissue were determined by mass spectrometry. The Cancer Genome Atlas was used to analyze gene expression related to the sphingolipid metabolism. Ceramide levels were higher in breast cancer tissue compared to both normal and peri-tumor breast tissue. Substrates and enzymes that generate ceramide were significantly increased in all three ceramide biosynthesis pathways in cancer. Further, higher levels of ceramide in breast cancer were associated with less aggressive cancer biology presented by Ki-67 index and nuclear grade of the cancer. Interestingly, patients with higher gene expressions of enzymes in the three major ceramide synthesis pathways showed significantly worse prognosis. This is the first study to reveal the clinical relevance of ceramide metabolism in breast cancer patients. We demonstrated that ceramide levels in breast cancer tissue were significantly higher than those in normal tissue, with activation of the three ceramide biosynthesis pathways. We also identified that ceramide levels have a significant association with aggressive phenotype and its enzymes have prognostic impact on breast cancer patients.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4499号. 学位記番号: 新大院博(医)甲第836号. 学位授与年月日: 平成30年9月20日
内容記述
内容記述タイプ Other
内容記述 Oncotarget. 2018, 9(28), 19874-19890.
書誌情報 発行日 2018-09-20
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.18632/oncotarget.24903
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2018-09-20
学位授与番号
学位授与番号 13101甲第4499号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第836号
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 08:45:04.450850
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3