{"created":"2021-03-01T06:34:24.173501+00:00","id":28576,"links":{},"metadata":{"_buckets":{"deposit":"74e4c94e-803f-4677-8589-f8dc9577d878"},"_deposit":{"id":"28576","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28576"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00028576","sets":["453:456","506:1624:1625:1630"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"49","bibliographicPageStart":"39","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"新潟大学保健学雑誌"},{"bibliographic_title":"新潟大学保健学雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background & Aims: The therapeutic potential of marrow stem cells for liver disease is currently unclear. The aim of this study was to investigate whether potentiating the chemotaxis ability of stromal cell-derived factor 1 could augment the engraftment of marrow stem cells and ameliorate tissue damage. Methods: Female mice reconstructed with β-galactosidase-positive male marrow cells were repeatedly injected with carbon tetrachloride to induce liver cirrhosis. The statuses of stromal cell-derived factor 1 and its inhibitor CD26 were examined by immunohistochemical staining, enzyme-linked immunosorbent assays and colorimetric assays. Recipients were treated with an inhibitory peptide for CD26（Diprotin A）together with granulocyte colony-stimulating factor, and the marrow-derived cells were tracked through the β-galactosidase activity or sex-determining region on the Y chromosome. Results: Stromal cell-derived factor 1 expression and CD26 activity were both significantly increased and marrow-derived hepatocytes were not observed in liver cirrhosis, suggesting that the potential of stem cell homing is impaired by liver damage. Granulocyte colony-stimulating factor only induced a few cell clusters comprising 2-6 marrow-derived hepatocytes at a late stage of liver cirrhosis. In contrast, when animals with liver cirrhosis were treated with Diprotin A after granulocyte colonystimulating factor-induced stem cell mobilization, marrow-derived hepatocytes increased to 2-4% of the total hepatocytes and both the serum albumin and hepatic hydroxyproline contents were ameliorated（p < .05）. Conclusions: Maintaining the chemotaxis ability of stromal cell-derived factor 1 may represent an effective strategy for validating stem cell therapy.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学医学部保健学科"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12680484","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21884617","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuda, Yasunobu"}],"nameIdentifiers":[{"nameIdentifier":"164502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakai, Toshifumi"}],"nameIdentifiers":[{"nameIdentifier":"164503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirose, Yuki"}],"nameIdentifiers":[{"nameIdentifier":"164504","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakata, Jun"}],"nameIdentifiers":[{"nameIdentifier":"164505","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"164506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Osawa, Mami"}],"nameIdentifiers":[{"nameIdentifier":"164507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimaki, Shun"}],"nameIdentifiers":[{"nameIdentifier":"164508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubota, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"164509","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-20"}],"displaytype":"detail","filename":"11(1)_39-49.pdf","filesize":[{"value":"4.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"11(1)_39-49.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/28576/files/11(1)_39-49.pdf"},"version_id":"9fb129cc-f2f9-4c01-9f10-f785b8909907"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD26","subitem_subject_scheme":"Other"},{"subitem_subject":"stromal cell-derived factor-1（SDF-1）","subitem_subject_scheme":"Other"},{"subitem_subject":"bone marrow stem cells","subitem_subject_scheme":"Other"},{"subitem_subject":"liver cirrhosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Blockade of CD26 Augments the Therapeutic Potential of Marrow Stem Cells in the Liver","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Blockade of CD26 Augments the Therapeutic Potential of Marrow Stem Cells in the Liver"},{"subitem_title":"Blockade of CD26 Augments the Therapeutic Potential of Marrow Stem Cells in the Liver","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1630"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-29"},"publish_date":"2016-02-29","publish_status":"0","recid":"28576","relation_version_is_last":true,"title":["Blockade of CD26 Augments the Therapeutic Potential of Marrow Stem Cells in the Liver"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:58:46.353769+00:00"}