{"_buckets": {"deposit": "74e4c94e-803f-4677-8589-f8dc9577d878"}, "_deposit": {"id": "28576", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28576"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00028576", "sets": ["456", "1630"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "49", "bibliographicPageStart": "39", "bibliographicVolumeNumber": "11", "bibliographic_titles": [{"bibliographic_title": "新潟大学保健学雑誌"}, {"bibliographic_title": "新潟大学保健学雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background \u0026 Aims: The therapeutic potential of marrow stem cells for liver disease is currently unclear. The aim of this study was to investigate whether potentiating the chemotaxis ability of stromal cell-derived factor 1 could augment the engraftment of marrow stem cells and ameliorate tissue damage. Methods: Female mice reconstructed with β-galactosidase-positive male marrow cells were repeatedly injected with carbon tetrachloride to induce liver cirrhosis. The statuses of stromal cell-derived factor 1 and its inhibitor CD26 were examined by immunohistochemical staining, enzyme-linked immunosorbent assays and colorimetric assays. Recipients were treated with an inhibitory peptide for CD26（Diprotin A）together with granulocyte colony-stimulating factor, and the marrow-derived cells were tracked through the β-galactosidase activity or sex-determining region on the Y chromosome. Results: Stromal cell-derived factor 1 expression and CD26 activity were both significantly increased and marrow-derived hepatocytes were not observed in liver cirrhosis, suggesting that the potential of stem cell homing is impaired by liver damage. Granulocyte colony-stimulating factor only induced a few cell clusters comprising 2-6 marrow-derived hepatocytes at a late stage of liver cirrhosis. In contrast, when animals with liver cirrhosis were treated with Diprotin A after granulocyte colonystimulating factor-induced stem cell mobilization, marrow-derived hepatocytes increased to 2-4% of the total hepatocytes and both the serum albumin and hepatic hydroxyproline contents were ameliorated（p \u003c .05）. Conclusions: Maintaining the chemotaxis ability of stromal cell-derived factor 1 may represent an effective strategy for validating stem cell therapy.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟大学医学部保健学科"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12680484", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "21884617", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsuda, Yasunobu"}], "nameIdentifiers": [{"nameIdentifier": "164502", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakai, Toshifumi"}], "nameIdentifiers": [{"nameIdentifier": "164503", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirose, Yuki"}], "nameIdentifiers": [{"nameIdentifier": "164504", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakata, Jun"}], "nameIdentifiers": [{"nameIdentifier": "164505", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "164506", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Osawa, Mami"}], "nameIdentifiers": [{"nameIdentifier": "164507", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujimaki, Shun"}], "nameIdentifiers": [{"nameIdentifier": "164508", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubota, Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "164509", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "11(1)_39-49.pdf", "filesize": [{"value": "4.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4000000.0, "url": {"label": "11(1)_39-49.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/28576/files/11(1)_39-49.pdf"}, "version_id": "9fb129cc-f2f9-4c01-9f10-f785b8909907"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "CD26", "subitem_subject_scheme": "Other"}, {"subitem_subject": "stromal cell-derived factor-1（SDF-1）", "subitem_subject_scheme": "Other"}, {"subitem_subject": "bone marrow stem cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "liver cirrhosis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Blockade of CD26 Augments the Therapeutic Potential of Marrow Stem Cells in the Liver", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Blockade of CD26 Augments the Therapeutic Potential of Marrow Stem Cells in the Liver"}, {"subitem_title": "Blockade of CD26 Augments the Therapeutic Potential of Marrow Stem Cells in the Liver", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1630"], "permalink_uri": "http://hdl.handle.net/10191/38942", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-02-29"}, "publish_date": "2016-02-29", "publish_status": "0", "recid": "28576", "relation": {}, "relation_version_is_last": true, "title": ["Blockade of CD26 Augments the Therapeutic Potential of Marrow Stem Cells in the Liver"], "weko_shared_id": null}