{"created":"2021-03-01T06:34:21.701572+00:00","id":28539,"links":{},"metadata":{"_buckets":{"deposit":"e069b5f0-3248-49c7-b00b-8eceeabb3023"},"_deposit":{"id":"28539","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28539"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00028539","sets":["453:456","506:1624:1625:1627"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Clinical significance of anti-dsDNA antibodies in patients with SLE"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"57","bibliographicPageStart":"51","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"新潟大学保健学雑誌"},{"bibliographic_title":"新潟大学保健学雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】全身性エリテマトーデス（systemic lupus erythematosus:SLE）における免疫グロブリンクラス別抗dsDNA抗体の測定意義を明らかにすることを目的に検討した。【方法】新潟大学第二内科に入院したSLE143例を用いた。組織検索例でⅢ，Ⅳ，Ⅴ型を，組織検索がない場合は尿蛋白0.5g/日以上を腎症ありとした。1.0μg/mlのdsDNAを96穴プレートに一晩固相化し，翌日，100倍希釈血清，10000倍希釈二次抗体（IgGとIgMクラス），TMB基質をそれぞれ60分，30分，20分反応させる。硫酸で反応を停止し，450nmで比色して免疫グロブリンクラス別抗dsDNA抗体を測定した。【結果】腎症あり群（65例）となし群（78例）で抗体価を比較したところ，IgMクラスは腎症なし群で有意に高値であったが，RIA法，IgGクラスは両群で差はなかった。IgMクラスとIgGクラスの比（IgM/IgG比）は，腎症なし群で有意に高値であった。【結語】IgMクラス抗dsDNA抗体により，腎症が抑制される可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"The aim of this study is to investigate the relationship between patterns of anti-dsDNA antibodies （Abs）and renal involvement in patients with SLE. The study involved 143 patients with SLE. Patients are divided into a group with renal involvement and without nephritis according to biopsy （class Ⅲ,Ⅳ,Ⅴ） or proteinuria≧0.5g/day. AntidsDNA Abs are investigated using the enzyme-linked immunosorbent assays （ELISA）. SLE patients without lupus nephritis had a statistically significant higher titer of IgM anti-dsDNA antibodies compared with patients with lupus nephritis. Farr assay and IgG anti-dsDNA antibodies were not different with both groups. The IgM/IgG ratio of antidsDNA Abs was significantly higher in patients without renal involvement than those with renal involvement. To conclude, the results of our study show that the measurement of anti-dsDNA isotypes may be a helpful tool in the assessment of patients with SLE.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"164223","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hoshi, Kaori"}]},{"nameIdentifiers":[{"nameIdentifier":"164224","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nakano, Masaaki"}]},{"nameIdentifiers":[{"nameIdentifier":"164225","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Narita, Ichiei"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学医学部保健学科"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12680484","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21884617","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"星, 佳織"}],"nameIdentifiers":[{"nameIdentifier":"164220","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野, 正明"}],"nameIdentifiers":[{"nameIdentifier":"164221","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"成田, 一衛"}],"nameIdentifiers":[{"nameIdentifier":"164222","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-20"}],"displaytype":"detail","filename":"14(1)_51-57.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"14(1)_51-57.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/28539/files/14(1)_51-57.pdf"},"version_id":"c5ccb4a5-8261-4cf8-b8cf-8852f4d1ddb8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SLE","subitem_subject_scheme":"Other"},{"subitem_subject":"抗dsDNA抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"ループス腎炎","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-dsDNA Abs","subitem_subject_scheme":"Other"},{"subitem_subject":"lupus nephritis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"全身性エリテマトーデスにおける抗二本鎖DNA抗体の免疫グロブリンクラス別測定の意義に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"全身性エリテマトーデスにおける抗二本鎖DNA抗体の免疫グロブリンクラス別測定の意義に関する研究"},{"subitem_title":"全身性エリテマトーデスにおける抗二本鎖DNA抗体の免疫グロブリンクラス別測定の意義に関する研究","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1627"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-03-28"},"publish_date":"2017-03-28","publish_status":"0","recid":"28539","relation_version_is_last":true,"title":["全身性エリテマトーデスにおける抗二本鎖DNA抗体の免疫グロブリンクラス別測定の意義に関する研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:58:45.316709+00:00"}