{"created":"2021-03-01T06:34:14.136080+00:00","id":28425,"links":{},"metadata":{"_buckets":{"deposit":"79f7fb53-0f98-4210-bee4-bed0e80333c1"},"_deposit":{"id":"28425","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28425"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00028425"},"item_7_alternative_title_1":{"attribute_name":"\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_alternative_title":"\u5927\u8178\u83cc\u306eC\uff53\uff52\u30b0\u30ed\u30fc\u30d0\u30eb\u5236\u5fa1\u30b7\u30b9\u30c6\u30e0\u306b\u3088\u308b\u8ee2\u5199\u5f8c\u8abf\u7bc0"}]},"item_7_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"63","bibliographicPageStart":"56","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"\u65b0\u6f5f\u5927\u5b66\u8fb2\u5b66\u90e8\u7814\u7a76\u5831\u544a"},{"bibliographic_title":"\u65b0\u6f5f\u5927\u5b66\u8fb2\u5b66\u90e8\u7814\u7a76\u5831\u544a","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"In many species of bacteria, the Csr (carbon storage regulator) global regulatory system coordinates the expression of various genes. In Escherichia coli, the central component of this system, CsrA, is a RNA-binding protein. The CsrA is a homodimer and binds to leader segments of target mRNAs, affecting their translation and stability. CsrA activity is regulated by two small non-coding RNAs, CsrB and CsrC. These RNAs contain multiple CsrA-binding sequences and act by sequestering CsrA. In this system, CsrA indirectly activates transcription of csrB and csrC through a two-component signal transduction system, BarA/UvrY. Another component of this system, CsrD, controls the degradation of CsrB and CsrC RNAs. CsrD contains GGDEF and EAL signaling domains, however, unlike typical GGDEF and EAL domain proteins, its activity does not involve cyclic di-GMP metabolism. The dramatic stabilization of CsrB and CsrC RNAs in a csrD mutant altered the expression of CsrA-regulated genes. The Csr components, CsrA, CsrB and CsrC RNAs, and CsrD, interact within the autoregulatory circuit that provides a homeostatic mechanism for control of CsrA activity.Csr (carbon strage regulator) \u30b0\u30ed\u30fc\u30d0\u30eb\u5236\u5fa1\u30b7\u30b9\u30c6\u30e0\u306f\u591a\u304f\u306e\u7d30\u83cc\u306b\u5b58\u5728\u3057\u3001\u69d8\u3005\u306a\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u3066\u3044\u308b\u3002\u5927\u8178\u83cc\u306b\u304a\u3044\u3066\u3001Csr\u30b7\u30b9\u30c6\u30e0\u306e\u6d3b\u6027\u306e\u4e2d\u5fc3\u306fRNA\u7d50\u5408\u86cb\u767d\u8ceaCsrA\u3067\u3042\u308b\u3002CsrA\u306f\u4e8c\u91cf\u4f53\u3092\u5f62\u6210\u3057\u3001\u6a19\u7684\u3068\u306a\u308bmRNA\u306e\u30ea\u30fc\u30c0\u30fc\u90e8\u4f4d\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067mRNA\u306e\u5b89\u5b9a\u6027\u3068\u7ffb\u8a33\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002CsrA\u306e\u6d3b\u6027\u306f2\u3064\u306e\u975e\u7ffb\u8a33\u578b\u306esmall RNA\u3001CsrB\u53ca\u3073CsrC\u3001\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u308b\u3002\u3053\u308c\u3089\u306esmall RNA\u306f\u8907\u6570\u306eCsrA\u7d50\u5408\u914d\u5217\u3092\u3082\u3063\u3066\u304a\u308a\u3001CsrA\u3092\u6355\u3089\u3048\u308b\u50cd\u304d\u3092\u3059\u308b\u3002Csr\u30b7\u30b9\u30c6\u30e0\u306b\u306f\u81ea\u5df1\u8abf\u7bc0\u56de\u8def\u304c\u5b58\u5728\u3057\u3001CsrA\u306f\u4e8c\u6210\u5206\u5236\u5fa1\u7cfb\u306eBarA/UvrY\u3092\u4ecb\u3057\u3066\u9593\u63a5\u7684\u306bcsrB\u3068csrC\u306e\u8ee2\u5199\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u3002Csr\u30b7\u30b9\u30c6\u30e0\u306e\u65b0\u305f\u306a\u69cb\u6210\u6210\u5206CsrD\u30bf\u30f3\u30d1\u30af\u8cea\u306fCsrB\u53ca\u3073CsrC RNA\u306e\u5206\u89e3\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3002CsrD\u306fGGDEF\u3068EAL\u306e2\u3064\u306e\u30c9\u30e1\u30a4\u30f3\u3092\u3082\u3063\u3066\u3044\u308b\u304c\u3001\u5178\u578b\u7684\u306aGGDEF-EAL\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u306f\u7570\u306a\u308a\u3001cyclic di-GMP\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3066\u3044\u306a\u3044\u3002csrD\u5909\u7570\u682a\u306b\u304a\u3044\u3066\u3001CsrB\u53ca\u3073CsrC RNA\u306f\u5287\u7684\u306b\u5b89\u5b9a\u3068\u306a\u308a\u3001\u305d\u308c\u306fCsrA\u304c\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5909\u5316\u3055\u305b\u305f\u3002Csr\u30b7\u30b9\u30c6\u30e0\u306e\u69cb\u6210\u6210\u5206\u3001CsrA\u3001CsrB\u3068CsrC\u306esmall 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Kazushi"}],"nameIdentifiers":[{"nameIdentifier":"163553","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-20"}],"displaytype":"detail","filename":"056-063.pdf","filesize":[{"value":"709.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"056-063.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/28425/files/056-063.pdf"},"version_id":"5c6204fc-8559-41c5-b1d0-cdae6241508d"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"Csr A","subitem_subject_scheme":"Other"},{"subitem_subject":"Csr system","subitem_subject_scheme":"Other"},{"subitem_subject":"EAL domain","subitem_subject_scheme":"Other"},{"subitem_subject":"GGDEF domain","subitem_subject_scheme":"Other"},{"subitem_subject":"small RNA","subitem_subject_scheme":"Other"},{"subitem_subject":"EAL \u30c9\u30e1\u30a4\u30f3","subitem_subject_scheme":"Other"},{"subitem_subject":"Csr \u30b7\u30b9\u30c6\u30e0","subitem_subject_scheme":"Other"},{"subitem_subject":"GGDEF \u30c9\u30e1\u30a4\u30f3","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Post-Transcriptional Regulation by the Csr Global Regulatory System in Escherichia coli","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"Post-Transcriptional Regulation by the Csr Global Regulatory System in Escherichia coli"},{"subitem_title":"Post-Transcriptional Regulation by the Csr Global Regulatory System in Escherichia 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