{"created":"2021-03-01T06:34:04.662509+00:00","id":28285,"links":{},"metadata":{"_buckets":{"deposit":"173d1078-82bd-4a0b-aa2f-0a9fb1aa06b9"},"_deposit":{"id":"28285","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28285"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00028285","sets":["453:456","485:872:1583:1589"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"春化の鍵遺伝子であるFLOWERING LOCUS Cの転写制御について"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"110","bibliographicPageStart":"105","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"新潟大学農学部研究報告"},{"bibliographic_title":"新潟大学農学部研究報告","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To adjust the timing of flowering, plants can sense the temperature and day length. Vernalization is a phenomenon where flowering is induced by a long period of low temperature, and has an important role in controlling flowering time. In Arabidopsis thaliana, FLOWERING LOCUS C (FLC) acts as a floral repressor, and transcription of FLC is repressed through the increase of tri-methylation of histone H3 Lysine 27 (H3K27me3) by vernalization. This transcriptional repression is caused by POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) that functions to modify the H3K27me3. Two types of long non-coding RNAs (lncRNA) from the intragenic region of FLC, COOLAIR and COLDAIR, are expressed by vernalization. Notably COLDAIR leads to an increase of H3K27me3 with PRC2 interaction. A detailed understanding of the regulatory mechanism of the FLC will provide a good model of other epigenetically regulated genes.","subitem_description_type":"Abstract"},{"subitem_description":"植物は温度や日長を認識することで開花するタイミングを調節している。春化は、植物が長期間の低温に遭遇することにより花成が誘導される現象であり、開花期を制御する重要な役割を担っている。シロイヌナズナ（Arabidopsis thaliana）の開花抑制遺伝子であるFLOWEING LOCUS C(FLC) では、春化によって、転写抑制にかかわるヒストンマークであるヒストンH3の27番目のリジン残基のトリメチル化（H3K27me3）を介した転写抑制が生じる。この遺伝子サイレンシングにはH3K27me3をターゲットとするPOLYCOMB RPRESSIVE COMPLEX 2（PRC2）複合体が関与する。これは動植物で保存された転写制御メカニズムである。FLC 遺伝子座内から転写される長鎖非翻訳RNA（long non-coding RNA: lncRNA）であるCOOLAIR とCOLDAIR は、春化によって誘導される。特に、COLDAIR はPRC2と結合することで、FLC 遺伝子座内のH3K27me3レベルの増加をもたらす。FLC の制御機構が詳細に理解されれば、他のエピジェネティックな制御を受ける遺伝子のモデルになるだろう。","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"162510","nameIdentifierScheme":"WEKO"}],"names":[{"name":"戸丸, 祐貴"}]},{"nameIdentifiers":[{"nameIdentifier":"162511","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長部, 謙二"}]},{"nameIdentifiers":[{"nameIdentifier":"162512","nameIdentifierScheme":"WEKO"}],"names":[{"name":"岡崎, 桂一"}]},{"nameIdentifiers":[{"nameIdentifier":"162513","nameIdentifierScheme":"WEKO"}],"names":[{"name":"藤本, 龍"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学農学部"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00183393","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858634","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tomaru, Yuki"}],"nameIdentifiers":[{"nameIdentifier":"162506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Osabe, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"162507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okazaki, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"162508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimoto, Ryo"}],"nameIdentifiers":[{"nameIdentifier":"162509","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-20"}],"displaytype":"detail","filename":"66(2)_105-110.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"66(2)_105-110.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/28285/files/66(2)_105-110.pdf"},"version_id":"22dbad37-b13d-4d35-877d-6cf3c75e9c42"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Arabidopsis thaliana","subitem_subject_scheme":"Other"},{"subitem_subject":"Transcriptional regulation","subitem_subject_scheme":"Other"},{"subitem_subject":"Epigenetics","subitem_subject_scheme":"Other"},{"subitem_subject":"Vernalization","subitem_subject_scheme":"Other"},{"subitem_subject":"シロイヌナズナ","subitem_subject_scheme":"Other"},{"subitem_subject":"転写制御","subitem_subject_scheme":"Other"},{"subitem_subject":"エピジェネティクス","subitem_subject_scheme":"Other"},{"subitem_subject":"春化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Transcriptional regulation of key gene of vernalization, FLOWERING LOCUS C","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Transcriptional regulation of key gene of vernalization, FLOWERING LOCUS C"},{"subitem_title":"Transcriptional regulation of key gene of vernalization, FLOWERING LOCUS C","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1589"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-04-07"},"publish_date":"2014-04-07","publish_status":"0","recid":"28285","relation_version_is_last":true,"title":["Transcriptional regulation of key gene of vernalization, FLOWERING LOCUS C"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:58:15.679510+00:00"}