@article{oai:niigata-u.repo.nii.ac.jp:00002626,
 author = {折田, 義正 and 下條, 文武 and 坂爪, 実 and 椎貝, 達夫 and 前田, 益孝 and 今井, 圓裕 and 藤井, 健 and 遠藤, 正之 and 神出, 毅一郎 and 羽田, 勝計 and 杉本, 俊郎 and 菱田, 明 and 高橋, 聡 and 細谷, 龍男 and 山本, 裕康 and 洞, 和彦 and 岡田, 洋一 and 保坂, 成俊 and 小口, 智雅 and 神應, 裕 and 西尾, 康英 and 矢野, 新太郎 and 相川, 一男 and 安井, 聖},
 issue = {7},
 journal = {The Japanese journal of nephrology, The Japanese journal of nephrology},
 month = {Oct},
 note = {Inulin clearance (Cin) is widely believed to be the gold standard of the glomerular filtration rate (GFR). However, in Japan, Cin has not been officially recognized by the Ministry of Health, Labour and Welfare of Japan for clinical use. Creatinine clearance (Ccr) has been used to estimate the renal function of patients, but there have been many studies in which Ccr estimates were GFR falsely high because the metabolism and tubular excretion of creatinine widely varied according to the pathophysiological state of the patient. In the present study, we determined Cin and Ccr simultaneously in 116 adult patients with renal diseases and diabetic mellitus. The clearance study was performed by the modified Wesson's method. The inulin preparation was FFI-1010 (Fuji Yakuhin Co. Ltd.). Inulin in serum and urine was determined by the newly devised enzymatic assay (Toyobo Co. Ltd.), which is specific for inulin. The mean Cin was 35.0±14.4ml/min/1.73m^2. The mean Ccr (the enzyme assay) was 63.6±24.1ml/min/1.73m^2 and that of the kinetic Jaffe assay was 55.3±19.3ml/min/1.73m^2. Mean Ccr/Cin was 1.93±0.73, 1.69±0.62, respectively. This ratio was significantly different (p＜0.05) in the degree of reduction of Cin, with values of 2.07±0.82 (Cin＜40ml/min/1.73m^2) and 1.64±0.32 (40＜Cin＜80ml/min/1.73m^2), respectively. Only 8 patients were classified into the same degree of reduced renal function (the Guideline of Japanese Society of Nephrology). The findings of this study suggest that the GFR determined by Ccr could misjudge the renal function of patient and delay the administration of proper treatment of the patient. Introduction of Cin into the clinical field is necessary to avoid tis delay.},
 pages = {804--812},
 title = {イヌリンクリアランスを用いた糸球体濾過量の評価 : クレアチニンクリアランスとの比較},
 volume = {47},
 year = {2005}
}