{"created":"2021-03-01T06:31:40.593420+00:00","id":26126,"links":{},"metadata":{"_buckets":{"deposit":"fc23eb21-16a5-4140-ae95-d24e4d1cacf1"},"_deposit":{"id":"26126","owners":[],"pid":{"revision_id":0,"type":"depid","value":"26126"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00026126","sets":["432:1291:1292:1343","453:456"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Separation and characterization of three forms of collagenase inhibitor from bovine gingiva"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1987-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"20","bibliographicPageStart":"11","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"新潟歯学会雑誌"},{"bibliographic_title":"新潟歯学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"私達は,約100gの牛歯肉から直接歯肉抽出液を得,CM-Sephadex, Con-A Sepharose, Sephadex, Heparin-Sepharoseの各カラム･クロマトグラフィーを使って3種のコラゲナーゼ･インヒビターを分画することが出来た｡1つは,Con-A Sepharoseに吸着し2% MDGPで溶出される分子量約38,000の糖タンパク質である〔αCon-A(+)〕このインヒビターは, リューマチ･コラゲナーゼ活性のみを抑える。他の2つは,Con-A Sepharoseに吸着せず分子量が各々約50,000と21,500である｡前者は人のリューマチ･コラゲナーゼのみならず,セリン･プロテアーゼのトリプシン,金属プロテアーゼのサーモリシンの活性もまた抑制した〔αCon-A(-)〕｡後者はリューマチ･コラゲナーゼの外に,弱いながらサーモリシンにもインヒビターとしての活性を示した〔β〕｡しかし,これら3つのコラゲナーゼ･インヒビターは,バクテリア･コラゲナーゼに対してはインヒビター活性を示さなかった｡又,熱(60℃,30分と90℃,30分)に対しても3種のインヒビターは安定であった｡しかし還元(5mM DTT)後のアルキル化(20mM MIA)によって,いずれのインヒビターもコラゲナーゼに対するインヒビター活性を失った。","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"154329","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Adachi, Yoshio"}]},{"nameIdentifiers":[{"nameIdentifier":"154330","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nohara, Hiroyoshi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟歯学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN0018300X","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03850153","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安達, 義雄"}],"nameIdentifiers":[{"nameIdentifier":"154327","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野原, 広美"}],"nameIdentifiers":[{"nameIdentifier":"154328","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-19"}],"displaytype":"detail","filename":"NS_17(2)_11-20.pdf","filesize":[{"value":"844.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"NS_17(2)_11-20.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/26126/files/NS_17(2)_11-20.pdf"},"version_id":"296bc2f6-cbd4-477d-af52-50af3302ef92"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"牛歯肉からの3種のコラゲナーゼ･インヒビターの分離とそれ等の性質について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"牛歯肉からの3種のコラゲナーゼ･インヒビターの分離とそれ等の性質について"},{"subitem_title":"牛歯肉からの3種のコラゲナーゼ･インヒビターの分離とそれ等の性質について","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1343"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-07-13"},"publish_date":"2012-07-13","publish_status":"0","recid":"26126","relation_version_is_last":true,"title":["牛歯肉からの3種のコラゲナーゼ･インヒビターの分離とそれ等の性質について"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:56:10.766095+00:00"}