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In each case, patchtest was performed and metal samples were analyzed by EPMA. From February 1990 to July 1995, the metal restorations were removed in 33 cases. Eighty patients (78.4%) revealed positive reactions on the patch test, and in 57 of these cases metal allergens were detected intraorally. Clinical diagnoses were classified as follows, 30 cases of pustulosis palmaris et plantaris, 28 cases of dermatitis and eczema, 19 cases of glossodynia and burning mouth syndrome, 15 cases of lichen planus, 8 cases of stomatitis and 2 unclassified cases. After allergen was removed in the 33 subjects, 27 of these (81.8%) experienced reduction of symptoms, but in 6 subjects, no effect was observed. The removed restorations were replaced with titanium or Au-Ag-Pd alloy. After treatment completion, no recurrent case was recorded in the 27 patients, thus allergy to certain dental metals may have caused the symptoms of those subjects.", "subitem_description_type": "Abstract"}, {"subitem_description": 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