@article{oai:niigata-u.repo.nii.ac.jp:00025774,
 author = {庭野, 和明},
 issue = {2},
 journal = {新潟歯学会雑誌, 新潟歯学会雑誌},
 month = {Dec},
 note = {The aim of this study was to reveal the properties of glass-ionomer restorative cements containing mixed antibacterial drugs related to compressive strength, disintegration, fluoride release, surface LSM images and bactericidal efficacy. Metronidazole, cefaclor and norfloxacin were mixed in the ratio of 3:1:1 in potency. Drug mixture was also mixed with GIC powders (two RM-GICs and one conventional GIC) by 0 (as control), 3, 5, 10wt%. In the preparation of specimens, each drug-cement combination was hand-mixed in accordance with the manufacturer's instructions specific for each GIC product. 1. Compressive Strength: Compressive strength was determined for specimens stored in distilled water using a universal testing machine at a cross-head speed of 0.75/min at each storage period. (24hours, 7days, 30days) 2. Disintegration: Cumulative disintegration (%) was determined at 23 hours, 7 days and 30 days respectively. 3. Fluoride Release: The amounts of fluoride released over 24 hours were determined with a fluoride ion selective electrode. Readings were taken at 24 hours, 7 days and 30 days after immersion in distilled water. 4. Bactericidal Efficacy: Specimens were placed on the BHI-blood agar plates inoculated with bacteria sampled from carious dentin, and incubated for 7 days at 37℃ in anaerobic condition. Inhibition zone was observed. Specimens stored in distilled water for 7 days were also tested. 5. LSM Observation: Specimens were prepared using wet 1200 grid abrasive paper, and observed identically at 1500-fold magnification immediately and after 30 day-immersion in distilled water. Results 1. The more amount of mixed drugs contained in cements, the greater inhibition zone on BHI blood agar was observed. However, this also resulted in decreased mechanical and physical properties of cements. 2. Increased fluoride release from mixed drug containing GIC was thought to be related mainly to disintegration of cement matrix. 3. GIC-containing mixed drug should be applied with careful case selection and take into consideration its mechanical and pharmacological properties., 人口の高齢化に伴い根面う蝕が増加傾向を示すことが報告されている｡高齢者には有病者が高率に存在し局所麻酔薬の使用が制限される症例も比較的多い。急性症状の存在しない根面う蝕に対し、細菌感染部を残置しても、その無菌化を試みて歯髄の保存を図る処置法は高齢者の根面う蝕治療において臨床上必要な選択肢であると考えられる｡本研究では根面残存感染歯質を無菌化する目的で充填用グラスアイオノマーセメントに三種混合抗菌剤を添加した場合の物性について、その圧縮強度、崩壊率、フッ素溶出性、走査型共焦点レーザー顕微鏡を用いた水中浸漬によるセメント表面の劣化の観察及び抗菌性から検討を行なった。その結果として、抗菌剤の添加量に伴い抗菌剤添加グラスアイオノマーセメントの抗菌性は向上するものの圧縮強度は低下の、崩壊率は上昇の傾向を示すこと、抗菌剤の添加によって増加したフッ素溶出はセメントの崩壊と関連が強いことが明らかとなった｡抗菌剤添加充填用グラスアイオノマーセメントは抗菌剤の特性、必要な材料強度を十分に考慮し、症例を選択する事によって臨床上応用可能と考えられた｡},
 pages = {25--35},
 title = {抗菌剤添加充填用グラスアイオノマーセメントに関する研究 : 圧縮強度、崩壊率、フッ素溶出性、走査型共焦点レーザー顕微鏡による観察および抗菌性},
 volume = {30},
 year = {2000}
}