@article{oai:niigata-u.repo.nii.ac.jp:00025571, author = {池田, 順行 and 星名, 秀行 and 斎藤, 正直 and 飯田, 明彦 and 高木, 律男 and 林, 孝文 and 宇都宮, 宏子 and 朔, 敬}, issue = {1}, journal = {新潟歯学会雑誌, 新潟歯学会雑誌}, month = {Jun}, note = {We report a case of granular cell tumor in the right side of the tongue. A 37-year-old man was referred to our clinic complaining of oppressive pain with a mass in the right side of the tongue. He found the mass three months ago. At first visit, there was a mass lesion 10x10mm in diameter with a rough surface.On ultrasonogram, the lesion with unclear borders invaded the intrinsic muscles. It was excised with a 10mm safety margin from the clinical border as is done with malignant tumors. Histopathologically, it consisted of the uniform cells which had many eosinophilic granules in their cytoplasm. In immunohistochemistry, the granules of the cytoplasm showed immunoreaction for S-100 protein, neuron-specific-enolase and cathepsinD and the margin of the cytoplasm showed immunoreaction for vimentin. Postoperatively, there has been no evidence of recurrence. The granular cell tumor is classified as a soft tissue benign tumor, however, it is very difficult to diagnose correctly from clinical appearance alone. We also compared our case with 97 other granular cell tumors that have been reported in Japan, clinico-pathologically., 今回われわれは、右側舌縁部に生じた顆粒細胞腫の1例を経験した。患者は37歳男性で、3ヵ月前に右側舌縁の腫瘤に気づき、接触痛が出現した。初診時、右側舌縁に表面粗造な10×10mmの腫瘤を認め、超音波検査で腫瘤は境界が不明瞭で深部は筋層に達していた。舌腫瘍の臨床診断のもと安全域を10mm設けた切除を行った。病理組織学的には、好酸性顆粒をもつ細胞の充実性増殖が認められ、被膜構造は明かではなかった。免疫組織化学的に、腫瘍細胞の細胞質内顆粒がS-100蛋白質、神経特異エノラーゼ、カテプシンD陽性を示し、細胞質辺縁部がビメンチン陽性であったことから、顆粒細胞腫と診断された。術後,再発はなく経過は良好である。顆粒細胞腫は身体各部の軟組織に発生する比較的まれな良性腫瘍であるが、その鑑別診断には注意を要する。今回、われわれは、本邦での顆粒細胞腫の報告97例を検索したので、臨床病理学的に考察をつけ加えた。}, pages = {49--53}, title = {舌顆粒細胞腫の1例と本邦報告97例の臨床病理学的解析}, volume = {36}, year = {2006} }