@article{oai:niigata-u.repo.nii.ac.jp:00025457, author = {吉津, 和憲 and 井上, 誠}, issue = {2}, journal = {新潟歯学会雑誌, 新潟歯学会雑誌}, month = {Dec}, note = {麻酔下の動物を用いて,末梢性に誘発された嚥下反射時の関連筋活動および気管内圧・食道内圧が呼吸運動とどのような協調を見せるかを検索した。実験には,全身麻酔下のウサギ10羽を使用し,蒸留水を口腔咽頭内に注入することにより嚥下反射を引き起こした。嚥下タイプを,嚥下開始が横隔膜筋電図活動のピーク前に来るEarly I 型,後に来るLate I 型,さらに横隔膜筋電図の活動開始前に嚥下が開始されるBefore I 型に分けた。今回記録した全嚥下の約9割は吸気相において嚥下反射が誘発される結果が得られた。平常時に呼吸関連活動を示す横隔膜筋電図や気管内圧は,嚥下タイプによって持続時間に差がみられ, Before I 型嚥下時の内圧発生持続時間は有意に短かった。横隔膜活動持続時間および気管内圧発生時間について,Early I 型ならびにLate I 型では,嚥下前後に比べて嚥下時には延長する結果が得られた。さらにEarly I 型では,呼吸頻度は嚥下が誘発される前から減少する傾向がみられたのに対してLate I 型やBefore I 型においては,嚥下時以外には呼吸頻度の変調は認められなかった。末梢刺激による感覚信号は,先に呼吸中枢へと作用しているように思われるが,呼吸リズムの変化は直後の嚥下反射の誘発を伴っていることから,嚥下運動への引き金となる起動神経群の活動が,嚥下運動発現前に呼吸中枢に作用したものであることが示唆された。, Coordination of respiration-related muscle activity and tracheal pressure during reflex swallowing was investigated in animals. The experiments were carried out in ten anesthetized male rabbits. Reflex swallowing was evoked by injection of distilled water into oropharyngeal region. Swallowing events recorded were divided into three types, depending on when the reflex was evoked : Early I type was defined as the one evoked before the peak of diaphragmatic burst, Late I type evoked after the peak of the diaphragmatic burst and Before I type evoked before the onset of diaphragmatic burst. About 90% of swallowing in the present study was evoked in the inspiratory phase. Respiration-related muscle activity was modulated during swallowing as well as the tracheal pressure and the modulatory pattern of them was different among the swallowing types. Particularly, the duration of positive-tracheal pressure was significantly shorter during Before I swallowing than Early I or Late I. The duration of diaphragmatic burst and tracheal positive pressure tended to be expanded during Early I and Late I swallowing as compared to before or after swallowing. Furthermore, the respiratory rate was decreased before the onset of Early I swallowing while that was not the case during Late I and Before I swallowing. The present study suggested that the peripheral inputs to the respiratory center resulted in the early modulation of respiratory-related muscle activity. However, the results that the modulation of respiratory pattern lead to the occurrence of swallowing may also suggest that the neuronal activity responsible for the initiation of swallowing changes that of the respiratory center before the onset of swallowing.}, pages = {117--121}, title = {嚥下反射誘発時の呼吸関連筋活動の変調}, volume = {39}, year = {2009} }