@article{oai:niigata-u.repo.nii.ac.jp:00025421, author = {野村, 務 and 新垣, 晋 and 齊藤, 力}, issue = {1}, journal = {新潟歯学会雑誌, 新潟歯学会雑誌}, month = {Jun}, note = {今回クエン酸シルデナフィル(バイアグラ)を服用後に口腔内に紫斑を伴った,血小板減少症の1例を経験したのでその概要を報告する。患者は82歳,男性であり,勃起不全(ED)のため,知人から入手したクエン酸シルデナフィル(用量不明)を2回服用した。その10日後より,左側下唇に血腫が出現し,耳鼻咽喉科,内科を受診するが症状改善ないため,発症より約5週後に当科を初診した。血腫は両側頬粘膜,口腔前庭,左側舌縁,左側下唇に認め,左側膝関節,左側眼球結膜にも認めた。血液検査にて血小板数が6,000/μl であったため,本学内科を紹介し,検査の結果,特発性血小板減少性紫斑病が疑われた。プレドニゾロンの投与により,血小板数は回復し,皮膚,口腔症状は消失した。クエン酸シルデナフィルが血小板に作用を及ぼす可能性が示唆され,今回の症例の如く,口腔粘膜症状を来すことがあり,内科と連携し,早期に診断,治療を進めることが重要であると思われた。, A case of thrombocytopenia with oral purpura following 2 doses of sildenafil citrate is described. The patient, an 82-year-old man, had taken sildenafil citrate on two occasions (actual doses unknown) for erectile dysfunction. The drug had not been prescribed by a physician. Ten days following the last medication, hematoma of the left lower lip was observed. The patient attended otorhinolaryngology and internal medicine departments but without relief of symptoms; he therefore attended our clinic. The hematoma were seen in bilateral cheek mucosa, lower oral vestibule, left lateral tongue, left lower lip, skin of the left knee and left bulbar conjunctiva. Platelet count was found to be 6,000/μl. The patient was referred to the internal medicine department of our university where on full examination he was suspected with idiopathic thrombocytopenic purpura. Following treatment with predoniserone, platelet count recovered to normal and skin and oral lesions disappeared. The possibility of side-effects of sildenafil citrate must be considered because of the presence of purpura of the oral mucosa. The importance of early diagnosis and treatment and collaboration with the department of internal medicine are emphasized.}, pages = {27--30}, title = {クエン酸シルデナフィル(バイアグラ)服用後に発症した血小板減少症の1例}, volume = {41}, year = {2011} }