@article{oai:niigata-u.repo.nii.ac.jp:00024706,
 author = {須田, 武保 and 岩渕, 三哉 and 渡辺, 英伸 and 岡本, 春彦 and 鹿嶋, 雄治 and 山井, 健介 and 下田, 聡 and 井上, 雄一朗 and 工藤, 進英 and 畠山, 勝義 and 小山, 真 and 武藤, 輝一},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {Localization of cellular and tissue carcinoembryonic antigen (CEA) was studied for the colorectal tumor by immunoperoxidase technique using monoclonal antibody against CEA (CM-010), and this specific localization was examined whether useful or not in differential diagnosis of the colorectal tumor. Twelve hyperplastic polyps, 107 adenomas, 188 carcinomas and 6 anticancer drug-induced colitis in formalin-fixed and paraffin-embedded specimens obtained by surgical operation and polypectomy were studied. The positive CEA staining was classified according to its localization in the cells as follows; Grade 1: CEA was positive only along the apical surface of the cells, Grade 3 : CEA was positive along the apical surface and basolateral cell membrane as well as in the cytoplasm and intraglandular material, Grade 2 : CEA was localized intermediately between Grade 1and Grade 3. The positive ratio and Grade 3 frequency of CEA were demonstrated respectively as follows; hyperplastic polyps 58.3% and 8.3%, adenomas 71.0% and 11.2%, and carcinomas 91.5% and 77.1%. Thease findings suggested Grade 3 localization of CEA was high frequency for the carcinoma and useful in differential diagnosis of the malignancy from the benign colorectal tumor.},
 pages = {357--365},
 title = {大腸腫瘍におけるCEAの免疫組織学的研究 : 良性と悪性の腫瘍を鑑別するための有用性について},
 volume = {100},
 year = {1986}
}