@article{oai:niigata-u.repo.nii.ac.jp:00024603,
 author = {森, 茂},
 issue = {9},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Sep},
 note = {A female patient, who died from the panencephalopathic type of the Creutzfeldt-Jakob disease (CJD), was examined for the pathogenic agent with her 10% brain extract, which was inoculated into guinea plgs through intracerebral route, resulting in the successful isolation of a transmissible agent. As far as I know, the agent isolation from the same type of patients was quite rare, those from the other histological types of the disease were repeatedly reported. The agent isolated could stably be transmitted in guinea pigs, inducing a lethal encephalopathy with degenerative changes in the thalamic area predominantly. In the serial transmission in guinea pigs, the agent was characteristic in manifesting relatively longer latent periods before causing illness: 728±122 days (fatality ratio, 2/4) at the initial isolation, then 400±25 days (5/6), 438±43 days (6/6), and 434±23 days (6/6) at the 2nd, 3rd, and 4th passage, respectively. During these passages, a substrain branched out of the original strain at the 4th passage with a markedly shortened latent period of 291± 23 days (6/6); the substrain thereafter exhibited similar short term latencies consistently. Besides these experimental CJD in guinea pigs, autoantibody to neuronal axon was examined in 4 patients. The method was an indirect immunoperoxidase staining of normal spinal cord sections prepared from human and guinea pig materials. The autoantibody was detected in 3 out of the 4 patients employing their serum specimens. In all of the antibody positive cases, the maximal titers were found at the time of death of patient: 1:5, 120 for one patient (Y.T.) at 3 years post onset (po) and 1:40 for the other 2 patients (M.IK. and T.M. )at nearly 1.5 years po, Suggesting the presence of more immunogens at the terminus of the clinical course. In addition, the patient Y.T. was revealed to have an antibody titer or 1:4 in the cerebrospinal fluid at 2 years po, at which the serum antibody titer was 1:640. Guinea pigs developing the experimental disease were also examined for the antibody titers, yet with entirely negative scores, probably due to their rapid death after onset of the illness. All of these findings on the experimental and clinical CJD were discussed from the pathognomonic viewpoint of the disease.},
 pages = {541--550},
 title = {Creutzfeldt-Jakob病病原体(越後1株)に関する研究 : モルモットによる分離,継代実験を中心として},
 volume = {100},
 year = {1986}
}