{"created":"2021-03-01T06:29:55.724903+00:00","id":24552,"links":{},"metadata":{"_buckets":{"deposit":"b8e4374d-1b0c-45f9-8dd5-f28d5a81060f"},"_deposit":{"id":"24552","owners":[],"pid":{"revision_id":0,"type":"depid","value":"24552"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00024552","sets":["453:456","471:537:538:1241"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Bone Metabolism of Children with Idiopathic Nephrotic Syndrome"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1986-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"613","bibliographicPageStart":"602","bibliographicVolumeNumber":"100","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Children with nephrotic syndrome are frequently at risk for osteodystrophy due to secondary hyperparathyroidism. Severe proteinuria is accompanied by loss of 25－OH－Vit. D3, which causes hyperparathyroidism following hypocalcemia. On the other hand, administred glucocorticoid suppresses protein synthesis in osteoblasts to cause osteoporosis, and disturbs absorption of calcium in the intestine, which also leads to hyperparathyroidism. In this study 66 children with nephrotic syndrome were examined to elucidate bone metabolism associated with proteinuria and glucocorticoid therapy. Children with nephrotic syndrome showed high free hydroxyproline in urine（a parameter of turnover of the bone）and high NcAMP（which correlates with PTH）, suggesting that administration of glucocorticoid for 1.5 to 2 months might cause secondary hyperparathyroidism. In children with nephrotic syndrome, the more glucocorticoid was given, the less bone mineral content was. These findings suggest that measurement of free Hyp and NcAMP, and analysis of bone construction with bone mineral analyzer or microdensitometer may be useful to estimate bone metabolism in children with nephrotic syndrome.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"146558","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Watanabe, Shigeko"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡辺, 繁子"}],"nameIdentifiers":[{"nameIdentifier":"146557","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-19"}],"displaytype":"detail","filename":"100(10)_602-613.pdf","filesize":[{"value":"930.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"100(10)_602-613.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/24552/files/100(10)_602-613.pdf"},"version_id":"3e121010-442c-4ca6-86a9-7e364cc1f019"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hyperparathyroidism","subitem_subject_scheme":"Other"},{"subitem_subject":"NcAMP","subitem_subject_scheme":"Other"},{"subitem_subject":"free Hydroxyproline","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone mineral Analyzer","subitem_subject_scheme":"Other"},{"subitem_subject":"Microdensitometer","subitem_subject_scheme":"Other"},{"subitem_subject":"副甲状腺機能亢進症","subitem_subject_scheme":"Other"},{"subitem_subject":"腎性cAMP","subitem_subject_scheme":"Other"},{"subitem_subject":"フリーハイドロキシプロリン","subitem_subject_scheme":"Other"},{"subitem_subject":"骨塩分析","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロデンシトメーター","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"特発性ネフローゼ症候群における骨代謝","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"特発性ネフローゼ症候群における骨代謝"},{"subitem_title":"特発性ネフローゼ症候群における骨代謝","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1241"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-11"},"publish_date":"2015-12-11","publish_status":"0","recid":"24552","relation_version_is_last":true,"title":["特発性ネフローゼ症候群における骨代謝"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:54:41.515252+00:00"}