{"created":"2021-03-01T06:29:55.659373+00:00","id":24551,"links":{},"metadata":{"_buckets":{"deposit":"ecb900cc-b2c2-49db-ba35-2da84e72b70f"},"_deposit":{"id":"24551","owners":[],"pid":{"revision_id":0,"type":"depid","value":"24551"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00024551","sets":["453:456","471:537:538:1241"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Characterization of human peripheral lymphocytes stained by anti-myelin-associated glycoprotein"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1986-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"601","bibliographicPageStart":"585","bibliographicVolumeNumber":"100","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We found that the same antigenic determinant as myelin-associated glycoprotein （MAG) of human central nervous system （CNS）exists on the cell surface of mononuclear cells in human peripheral blood, which was counted to 8.5±2.7% of mononuclear cells from 41 healthy individuals when stained by anti-MAG rabbit antisera. In a two-color immunofluorescence study, it seems that MAG-positive cells are a subset of Leu-7 positive cells and most but not all MAG-positive cells reveal Leu-7^+ Leu-11^+. In some patients with multiple sclerosis, the percentage of MAG positive cells was reduced but which was not related to disease activity and was not a pathognomonic feature of multiple sclerosis. Four of 14 patients with multiple sclerosis showed a normal number of Leu-7 positive cells and a reduced number of MAG positive cells. Human mononuclear cells conjugated with K-562, target cells of human natural killer（NK）cells, were stained by anti-Leu-7 and also by anti-MAG antisera. The remaining human NK activity after treatment of anti-MAG monoclonal mouse IgM or anti-Leu-7 antibody and complement revealed 13.4% and 15.1%, respectively（untreated NK activity was 40.8%）but NK activity could be abrogated by anti-Leu-11 and complement. Our findings suggest that“MAG”is a useful marker of human NK cells and NK cells may be influenced by anti-MAG antibody if it is found in the sera as anti-lymphocytotoxic antibody.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"146556","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tanaka, Masami"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 正美"}],"nameIdentifiers":[{"nameIdentifier":"146555","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-19"}],"displaytype":"detail","filename":"100(10)_585-601.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"100(10)_585-601.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/24551/files/100(10)_585-601.pdf"},"version_id":"aa258ab6-f544-4bd5-9792-881171aa2fca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"myelin-associated glycoprotein","subitem_subject_scheme":"Other"},{"subitem_subject":"natural killer","subitem_subject_scheme":"Other"},{"subitem_subject":"demyelination","subitem_subject_scheme":"Other"},{"subitem_subject":"lymphocytotoxic antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"ナチュラルキラー","subitem_subject_scheme":"Other"},{"subitem_subject":"脱髄","subitem_subject_scheme":"Other"},{"subitem_subject":"抗リンパ球抗体","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗Myelin-associated glycoprotein抗体により染色されるヒト末梢血単核球の性質","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗Myelin-associated glycoprotein抗体により染色されるヒト末梢血単核球の性質"},{"subitem_title":"抗Myelin-associated glycoprotein抗体により染色されるヒト末梢血単核球の性質","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1241"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-11"},"publish_date":"2015-12-11","publish_status":"0","recid":"24551","relation_version_is_last":true,"title":["抗Myelin-associated glycoprotein抗体により染色されるヒト末梢血単核球の性質"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:54:41.320936+00:00"}