@article{oai:niigata-u.repo.nii.ac.jp:00024551,
 author = {田中, 正美},
 issue = {10},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Oct},
 note = {We found that the same antigenic determinant as myelin-associated glycoprotein （MAG) of human central nervous system （CNS）exists on the cell surface of mononuclear cells in human peripheral blood, which was counted to 8.5±2.7% of mononuclear cells from 41 healthy individuals when stained by anti-MAG rabbit antisera. In a two-color immunofluorescence study, it seems that MAG-positive cells are a subset of Leu-7 positive cells and most but not all MAG-positive cells reveal Leu-7^+ Leu-11^+. In some patients with multiple sclerosis, the percentage of MAG positive cells was reduced but which was not related to disease activity and was not a pathognomonic feature of multiple sclerosis. Four of 14 patients with multiple sclerosis showed a normal number of Leu-7 positive cells and a reduced number of MAG positive cells. Human mononuclear cells conjugated with K-562, target cells of human natural killer（NK）cells, were stained by anti-Leu-7 and also by anti-MAG antisera. The remaining human NK activity after treatment of anti-MAG monoclonal mouse IgM or anti-Leu-7 antibody and complement revealed 13.4% and 15.1%, respectively（untreated NK activity was 40.8%）but NK activity could be abrogated by anti-Leu-11 and complement. Our findings suggest that“MAG”is a useful marker of human NK cells and NK cells may be influenced by anti-MAG antibody if it is found in the sera as anti-lymphocytotoxic antibody.},
 pages = {585--601},
 title = {抗Myelin-associated glycoprotein抗体により染色されるヒト末梢血単核球の性質},
 volume = {100},
 year = {1986}
}