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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第100巻第10号

抗Myelin-associated glycoprotein抗体により染色されるヒト末梢血単核球の性質

http://hdl.handle.net/10191/35499
http://hdl.handle.net/10191/35499
35000235-dcc6-4f5b-af14-abbdaa5f50d1
名前 / ファイル ライセンス アクション
100(10)_585-601.pdf 100(10)_585-601.pdf (2.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-12-11
タイトル
タイトル 抗Myelin-associated glycoprotein抗体により染色されるヒト末梢血単核球の性質
タイトル
言語 en
タイトル 抗Myelin-associated glycoprotein抗体により染色されるヒト末梢血単核球の性質
言語
言語 jpn
キーワード
主題Scheme Other
主題 myelin-associated glycoprotein
キーワード
主題Scheme Other
主題 natural killer
キーワード
主題Scheme Other
主題 demyelination
キーワード
主題Scheme Other
主題 lymphocytotoxic antibody
キーワード
主題Scheme Other
主題 ナチュラルキラー
キーワード
主題Scheme Other
主題 脱髄
キーワード
主題Scheme Other
主題 抗リンパ球抗体
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Characterization of human peripheral lymphocytes stained by anti-myelin-associated glycoprotein
著者 田中, 正美

× 田中, 正美

WEKO 146555

田中, 正美

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著者別名
識別子 146556
識別子Scheme WEKO
姓名 Tanaka, Masami
抄録
内容記述タイプ Abstract
内容記述 We found that the same antigenic determinant as myelin-associated glycoprotein (MAG) of human central nervous system (CNS)exists on the cell surface of mononuclear cells in human peripheral blood, which was counted to 8.5±2.7% of mononuclear cells from 41 healthy individuals when stained by anti-MAG rabbit antisera. In a two-color immunofluorescence study, it seems that MAG-positive cells are a subset of Leu-7 positive cells and most but not all MAG-positive cells reveal Leu-7^+ Leu-11^+. In some patients with multiple sclerosis, the percentage of MAG positive cells was reduced but which was not related to disease activity and was not a pathognomonic feature of multiple sclerosis. Four of 14 patients with multiple sclerosis showed a normal number of Leu-7 positive cells and a reduced number of MAG positive cells. Human mononuclear cells conjugated with K-562, target cells of human natural killer(NK)cells, were stained by anti-Leu-7 and also by anti-MAG antisera. The remaining human NK activity after treatment of anti-MAG monoclonal mouse IgM or anti-Leu-7 antibody and complement revealed 13.4% and 15.1%, respectively(untreated NK activity was 40.8%)but NK activity could be abrogated by anti-Leu-11 and complement. Our findings suggest that“MAG”is a useful marker of human NK cells and NK cells may be influenced by anti-MAG antibody if it is found in the sera as anti-lymphocytotoxic antibody.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 100, 号 10, p. 585-601, 発行日 1986-10
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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