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抗Myelin-associated glycoprotein抗体により染色されるヒト末梢血単核球の性質
http://hdl.handle.net/10191/35499
http://hdl.handle.net/10191/3549935000235-dcc6-4f5b-af14-abbdaa5f50d1
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-12-11 | |||||
タイトル | ||||||
タイトル | 抗Myelin-associated glycoprotein抗体により染色されるヒト末梢血単核球の性質 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 抗Myelin-associated glycoprotein抗体により染色されるヒト末梢血単核球の性質 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myelin-associated glycoprotein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | natural killer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | demyelination | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lymphocytotoxic antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ナチュラルキラー | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 脱髄 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 抗リンパ球抗体 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Characterization of human peripheral lymphocytes stained by anti-myelin-associated glycoprotein | |||||
著者 |
田中, 正美
× 田中, 正美 |
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著者別名 | ||||||
識別子 | 146556 | |||||
識別子Scheme | WEKO | |||||
姓名 | Tanaka, Masami | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We found that the same antigenic determinant as myelin-associated glycoprotein (MAG) of human central nervous system (CNS)exists on the cell surface of mononuclear cells in human peripheral blood, which was counted to 8.5±2.7% of mononuclear cells from 41 healthy individuals when stained by anti-MAG rabbit antisera. In a two-color immunofluorescence study, it seems that MAG-positive cells are a subset of Leu-7 positive cells and most but not all MAG-positive cells reveal Leu-7^+ Leu-11^+. In some patients with multiple sclerosis, the percentage of MAG positive cells was reduced but which was not related to disease activity and was not a pathognomonic feature of multiple sclerosis. Four of 14 patients with multiple sclerosis showed a normal number of Leu-7 positive cells and a reduced number of MAG positive cells. Human mononuclear cells conjugated with K-562, target cells of human natural killer(NK)cells, were stained by anti-Leu-7 and also by anti-MAG antisera. The remaining human NK activity after treatment of anti-MAG monoclonal mouse IgM or anti-Leu-7 antibody and complement revealed 13.4% and 15.1%, respectively(untreated NK activity was 40.8%)but NK activity could be abrogated by anti-Leu-11 and complement. Our findings suggest that“MAG”is a useful marker of human NK cells and NK cells may be influenced by anti-MAG antibody if it is found in the sera as anti-lymphocytotoxic antibody. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 100, 号 10, p. 585-601, 発行日 1986-10 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |