@article{oai:niigata-u.repo.nii.ac.jp:00024280,
 author = {新村, 末雄 and 前田, 宜俊 and 加藤, 明子 and 藤沢, 信義 and 佐藤, 徳光 and 浜田, 忠弥},
 issue = {2},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Feb},
 note = {The fluctuation of serum antibody titers in Hantaan virus-inoculated rats（Wistar, male）and mice（ICR, female）was observed by the indirect immunofluorescent staining. The activities of serum GOT, GPT and LDH were also examined by the clinical biochemical assays. Hantaan virus（strain: 76－118）was inoculated intraperitoneally to rats（1.6×10^5－1.6×10^6 VAIU）and mice（0.8×10^5VAIU）, and in both species it produced an asymptomatic infection. In the rats, high antibody titers ranging from 1: 512 to 1: 2048 were produced between 2 to 5 weeks after inoculation. The highest antibody titer was usually detected about 3 weeks after inoculation. The antibody titers decreased temporarily and were retained at low levels up to 10 weeks after inoculation. In some individuals, antibody titers increased again to 1: 2048 about 7 to 10 weeks after inoculation. The activities of serum GOT and GPT in almost the infected rats were values in normal range. However, the values of LDH were undoubtedly high far from the normal range. In the mice, the antibody appeared as early as two weeks after inoculation. The highest antibody titers ranging from 1: 128 to 1: 2048 were detected about 4 weeks after inoculation. In some individuals, high antibody titers of 1: 2048 were observed at 8 to 10 weeks after inoculation. The activities of serum GOT, GPT and LDH were all in normal range.},
 pages = {126--132},
 title = {Hantaanウイルスを接種したラット及びマウスの血清抗体価と2,3血清臨床生化学値の推移},
 volume = {101},
 year = {1987}
}