@article{oai:niigata-u.repo.nii.ac.jp:00024234, author = {小島, 秀男 and 品田, 章二 and 吉川, 明}, issue = {3}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Mar}, note = {Three hundred and eighteen times plasma exchange (PE) using centrifuge type plasma-cell separator (PEX) were performed for 44 patients since April 1982. Support of hepatic function or removal of toxic substance(s) in acute or chronic hepatic failure was the most frequent (25 cases) reason for PE. Other conditions needed for PE were removal of autoantibodies or immune complex, hyperviscosity syndrome, hyperlipemia, Rh incompatible pregnancy and so on. One patient of 8 fulminant hepatitits was saved her life by PE. Effect, recovery from hepatic encephalopathy, of PE in chronic hepatic failure was temporal and no patient seemed to be prolonged their life by PE. The best effect of PE was observed in cases with hyperviscosity syndrome and hyperlipemia. Fresh frozen plasma (FFP) was employed as replacement fluid in 317 times PE for 43 patients, and plasmanate was used only in one patient as substitution. 25,824 units of FFP were transfused into 715 patients in 1985, and 2,580 units were used for 8 patients as substitute fluid in PE with PEX. For the purpose of lowering substances existing abnormal amount in blood by PE, operator can calculate percent reduction of the substance by following formula. Albumin solution or synthtic plasma expandres should be used solitary or combination with FFP in case calculated reduction of physiological substances does not lose their action.}, pages = {161--164}, title = {3)-1 血漿交換と新鮮凍結血漿(シンポジウム 血液製剤の輸血適応と問題点, 1986年, 第420回新潟医学会例会)}, volume = {101}, year = {1987} }