@article{oai:niigata-u.repo.nii.ac.jp:00024121,
 author = {遠藤, 直人},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {The effect of pulsing electromagnetic fields (PEMF) on growth-cartilage cells was examined at the cellular level. Growth-cartilage cells were isolated from the ribs of young male rabbits. After cultured chondrocytes were reached subconfluency, they were exposed to vertically directed PEMF of average 2.4gauss, 15.4Hz. The effect of PEMF stimuli on the expression of the differentiated phenotype was evaluated in the light of PTH-responses using cAMP, induction of ODC and synthesis of GAG. And then the effect of PEMF on proliferation of cultured chondrocytes was examined. The following results were obtained. 1. The basal cAMP level treated with PBS was not changed by PEMF stimuli. 2. Cyclic AMP level treated with PTH was markedly elevated by PEMF. 3. Induction of ODC by PTH and synthesis of GAG by PTH were also enhanced by PEMF. 4. Enhancement of GAG-synthesis by PTH was changed by neither Verapamil nor EGTA. 5. DNA synthesis of cultured chondrocytes was not enhanced by PEMF. On the basis of these results it was concluded that PEMF stimulated differentiation or expression of the differentiated phenotype of chondrocytes.},
 pages = {367--381},
 title = {パルス電磁場刺激が培養成長軟骨細胞の分化・増殖機能に及ぼす影響についての実験的研究},
 volume = {101},
 year = {1987}
}