@article{oai:niigata-u.repo.nii.ac.jp:00023722,
 author = {黒木, 瑞雄 and 田中, 隆一 and 横山, 元晴 and 佐藤, 宏 and 田村, 哲郎},
 issue = {11},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Nov},
 note = {Pituitary adenomas can be safely treated by transsphenoidal microsurgery. Between 1978 and March, 1987, 130 patients with functioning pituitary adenomas underwent transsphenoidal adenomectomy at our clinic. There were 75 cases of prolactinoma, 43 of acromegaly and 12 of Cushing's disease. From the surgical point of view, peritumoral tissue resection after simple adenomectomy (radical removal) is essential for a better outcome. In this series, after radical removal of adenomas, postoperative normalization based on endocrinological studies was achieved in 100% of 15 cases of prolactinoma, 92% of 14 cases of acromegaly and 100% of 8 cases of Cushing's disease, while after intracapsular removal of adenomas, only a small number of cases were endocrinologically improved. In cases of invasive adenomas where radical tumor removal was impossible, pateints received subsequent postoperative therapies. For the patients with prolactinoma, further treatment with bromocriptine was very effective and for those with acromegaly, either bromocriptine or radiation given alone or in combination was also effective. Especially, further radiation therapy for acromegaly with mild postoperative elevation of GH levels showed a good result. As for Cushing's disease, however, no effective additional therapy has been proved yet, and radical tumor removal has the most major role in its management. Fortunately, patients with Cushing's disease are good candidates for this surgery because most cases are microadenomas.},
 pages = {731--737},
 title = {6) ホルモン産生下垂体腺腫の外科的治療(シンポジウム ホルモン産生下垂体腺腫の臨床, 第427回新潟医学会)},
 volume = {101},
 year = {1987}
}