@article{oai:niigata-u.repo.nii.ac.jp:00023720, author = {鴨井, 久司}, issue = {11}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Nov}, note = {The basic and clinical features of reported 83 patients with TSH-secreting pituitary adenoma are reviewed. Most patients had diffuse goiters and thyro-toxicosis, and a few patients euthyroid or hypothyroid state. The levels of blood TSH were varied, but no suppressed levels were observed. Alpha-subunit to TSH molar elevated. GH or PRL levels were not uncommon but were infrequently associated with acromegaly or amenorrhea-galactorrhea. No case of Cushing' disease was reported. Disturbance of visual field was common. Most patients had macroadenoma with chromophobe. Both TSH and GH granules were frequently observed by immunohistochemistry or electron microscope. Treatment of the disorder required pituitary surgery with transshenoidal and or/frontal approach, irradiation, or both.}, pages = {717--727}, title = {4) TSH産生下垂体腺腫 : その現状と問題点(シンポジウム ホルモン産生下垂体腺腫の臨床, 第427回新潟医学会)}, volume = {101}, year = {1987} }