@article{oai:niigata-u.repo.nii.ac.jp:00023718,
 author = {金子, 兼三},
 issue = {11},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Nov},
 note = {In 54 patients with acromegaly on admission, their chief complains mainly consisted of further examination for diabetes mellitus in 16 patients (30%), headache and/or visual disturbance due to pituitary adenoma in 11 patients (20%), finger numbness due to carpal tunnel syndrome in 4 patients (7%) and amenorrhea and galactorrhea in 4 patients (7%). Another patients had no direct complains as the illness: 2 patients (4%) had paid a visit to hospital because of their body changes and 11 patients (20%) had been pointed out acromegaly when they had medical check-up. These findings indicate that acromegalic patients who perceive the acromegalic alterations by their selves are rare. On the laboratory data, plasma somatomedin C levels increased more than 2.0 U/ml in all 8 patients who had more than 5.0 ng/ml of GH levels, suggesting an useful marker for diagnosis of acromegaly. In about 80% acromegalic cases, the i.v. injection of 500μg of synthetic TRH (TRH test) provoked the paradoxical increase in plasma GH levels and the oral administration of glucose (OGTT) did not suppressed the high GH levels to normal levels. In 6 acromegalie patients, GH levels showed variable responses to the i.v. injection of 100μg of synthetic GRF(1-44)-NH2 (GRF test): 1 patient with hyperresponse, 1 patient without response and 4 patients with delayed and slight response. These results indicate that TRH test and OGTT are useful for diagnosis of acromegaly, while GRF test is not useful. In conclusion, acromegalic patients who perceived acromegalic changes by their selves are rare, and measurement of plasma somatomedin C and TRH test and OGTT are useful for diagnosis of acromegaly.},
 pages = {703--707},
 title = {2) 末端肥大症の診断(シンポジウム ホルモン産生下垂体腺腫の臨床, 第427回新潟医学会)},
 volume = {101},
 year = {1987}
}