@article{oai:niigata-u.repo.nii.ac.jp:00023512,
 author = {吉田, 俊明},
 issue = {4},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Apr},
 note = {The methodology of NK assay was investigated using K562 cell line as target cells and NK activity of peripheral blood lymphocytes (PBL) obtained from patients with various liver diseases was measured. The susceptibility of K562 cells to NK cell depended on their cell cycle phases, Therefore, it was suggested that NK activity of the same healthy donors should be measured simultaneously in each assay. The NK activity of PBC, as well as LC, was significantly lower than that of other liver diseases. Any suppressive factors against NK activity, however, were not detected in sera from PBC. Serial change of NK activity of 11 HBsAg-positive patients treated with interferon (IFN) was investigated. The augmented NK activity was observed only in the first and second week during IFN treatment and it returned to previous level after the fourth week. Patients with HCC who showed lower NK activity had poorer life prognosis than those who possessed normal NK activity.},
 pages = {220--228},
 title = {各種肝疾患における NK 活性の動向と NK 活性測定に関する基礎的検討},
 volume = {102},
 year = {1988}
}