@article{oai:niigata-u.repo.nii.ac.jp:00023453, author = {桧森, 昌門}, issue = {6}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Jun}, note = {Fibrotic process in liver diseases is based on the quantitative changes of extracellular matrix components. In this study, the localization of proteodermatan sulfate (PDs) was investigated in 55 cases with various liver diseases. Polyclonal antibodies to the core protein of PDs isolated and purified from human placenta, fibronectin, laminin and type III collagen were used for this purpose. Results indicated that PDs was mainly localized at the matured fibrotic areas rather than the areas of liver cell necrosis or of inflammatory cell infiltration where new fibrogenesis was predicted. These data suggest that PDs has more close interrelationship with matured collagen fibers (type I collagen) in contrast to fibronectin or type III collagen and that PDs plays an important role in the conservation of hepatic fibrosis rather than in new fibrogenesis.}, pages = {365--371}, title = {各種肝疾患におけるプロテオデルマタン硫酸の局在に関する検討}, volume = {102}, year = {1988} }